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Background <p>−1031 (T/C) and AA for − 308 (G/A) showing a higher risk for disease susceptibility (OR = 3.5 and 8.7, respectively) and severity (OR = 1.99 and 8.59, respectively). Elevated levels of all biochemical markers were significantly correlated with higher severity of disease. Haplotype analysis demonstrated that individuals with variants at both loci exhibited the highest risk (OR = 3.67) for COVID-19.</p> Conclusion <p>These findings suggest that TNF-α polymorphisms may serve as potential genetic markers for predicting COVID-19 susceptibility and progression in South Indian population.</p>

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Association of TNF-⍺ promoter polymorphisms with COVID-19 susceptibility and severity: a study from South India

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月6日

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  • M. L. N. Deepika,
  • Aryan Gupta,
  • C. Lalitha Pavani

摘要

Background

−1031 (T/C) and AA for − 308 (G/A) showing a higher risk for disease susceptibility (OR = 3.5 and 8.7, respectively) and severity (OR = 1.99 and 8.59, respectively). Elevated levels of all biochemical markers were significantly correlated with higher severity of disease. Haplotype analysis demonstrated that individuals with variants at both loci exhibited the highest risk (OR = 3.67) for COVID-19.

Conclusion

These findings suggest that TNF-α polymorphisms may serve as potential genetic markers for predicting COVID-19 susceptibility and progression in South Indian population.