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<p>This critical appraisal reviews the article by Sidiq et al. on transporter gene polymorphisms and metformin efficacy in type 2 diabetes. The study strengthens evidence linking SLC22A1 and SLC47A1 variants to treatment response. We highlight the limited clinical use of genetic screening, particularly in low-resource settings, and call for inclusion of diverse populations and multi-omic approaches to enhance predictive value. Affordable genotyping and decision-support tools are essential for translating these findings into practice and advancing personalized diabetes therapy.</p>

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Critical appraisal of transporter gene polymorphisms on metformin efficacy in type 2 diabetes mellitus

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月31日

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  • Muhammad Khizar,
  • Muhammad Zaib,
  • Hasibullah Aminpoor,
  • Hasiba Karimi

摘要

This critical appraisal reviews the article by Sidiq et al. on transporter gene polymorphisms and metformin efficacy in type 2 diabetes. The study strengthens evidence linking SLC22A1 and SLC47A1 variants to treatment response. We highlight the limited clinical use of genetic screening, particularly in low-resource settings, and call for inclusion of diverse populations and multi-omic approaches to enhance predictive value. Affordable genotyping and decision-support tools are essential for translating these findings into practice and advancing personalized diabetes therapy.