Association between estrogen receptor-1 gene polymorphisms (rs1801132, rs2228480, rs2234693) and migraine susceptibility: an unveiling association through a comprehensive meta-analysis

This meta-analysis aims to find the relationship of ESR-1 gene polymorphisms (rs1801132, rs2228480, and rs2234693) with migraine risk among Caucasian and Asian populations.

To perform the present meta-analysis a search was carried out across several databases. The data obtained from the databases were analysed statistically using Review Manager 5.4 and MetaGenyo software. A total of 20 case–control studies were selected among them 12 articles were consisting of seven articles belonging to rs1801132, five articles belonging to rs2228480, and six articles belonging to rs2234693 for revealing the relationship between ESR-1 gene polymorphisms (rs1801132, rs2228480, and rs2234693) and migraine risk. The protocol for the present meta-analysis was registered (PROSPERO ID Number: 441920).

A total of 20 articles were included in this meta-analysis. According to the findings of this study, people with ESR-1 (rs1801132, rs2228480, and rs2234693 did not show an association with migraine risk in the allelic, recessive, dominant, and over-dominant models.

However, the results from the present meta-analysis are conflicting from the previously meta-analysis reports. Further research is needed to unravel the complex genetic basis of this debilitating condition.