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<p>This study investigated the effects of microencapsulated sodium butyrate (MSB) on production performance, reproductive hormone profiles, and gut microbiota-metabolite interactions in late-laying quails. Dietary MSB supplementation significantly increased laying rate and early egg weight and elevated serum FSH and LH concentrations, suggesting a potential involvement of reproductive endocrine regulation. MSB enhanced gut microbial richness and enriched fiber-fermenting, SCFA-associated taxa such as Lachnospiraceae, Ruminococcaceae and Bacteroides, while co-occurrence network analysis revealed increased connectivity and robustness of the microbial community. Untargeted metabolomics showed coordinated changes in amino acid derivatives, short peptides and lipid-like molecules. Exploratory mediation analysis further suggested that specific metabolites may be involved in the associations between MSB-responsive bacteria and host reproductive traits. Specifically, the dipeptide Pro-Trp and N-arachidonoyl phenylalanine were potentially associated with the relationship between decreased <i>s__uncultured_bacterium_o__RF39</i> and improved laying rate, whereas N-docosahexaenoyl tryptophan appeared to link increased <i>s__unclassified_f__Lachnospiraceae</i> to higher FSH concentrations. These findings indicate that MSB may improve reproductive performance in aging quails by reshaping the gut microbiota and its metabolite outputs in a manner that supports reproductive endocrine function. Overall, this study provides novel insights supporting the use of microencapsulated sodium butyrate as a functional feed additive for extending the productive lifespan of laying quails.</p>

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Multi-omics insights into the role of microencapsulated sodium butyrate on production performance in aged quails

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月27日

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  • Yibin Xu,
  • Sisi Li,
  • Liqing Guo,
  • Shanjie Han,
  • Yu Zhang,
  • Ying Yan,
  • Hui Zhang,
  • Yanfen Ma,
  • Wei Shi,
  • Fujun Wan,
  • Xin Liu,
  • Lizhi Lu

摘要

This study investigated the effects of microencapsulated sodium butyrate (MSB) on production performance, reproductive hormone profiles, and gut microbiota-metabolite interactions in late-laying quails. Dietary MSB supplementation significantly increased laying rate and early egg weight and elevated serum FSH and LH concentrations, suggesting a potential involvement of reproductive endocrine regulation. MSB enhanced gut microbial richness and enriched fiber-fermenting, SCFA-associated taxa such as Lachnospiraceae, Ruminococcaceae and Bacteroides, while co-occurrence network analysis revealed increased connectivity and robustness of the microbial community. Untargeted metabolomics showed coordinated changes in amino acid derivatives, short peptides and lipid-like molecules. Exploratory mediation analysis further suggested that specific metabolites may be involved in the associations between MSB-responsive bacteria and host reproductive traits. Specifically, the dipeptide Pro-Trp and N-arachidonoyl phenylalanine were potentially associated with the relationship between decreased s__uncultured_bacterium_o__RF39 and improved laying rate, whereas N-docosahexaenoyl tryptophan appeared to link increased s__unclassified_f__Lachnospiraceae to higher FSH concentrations. These findings indicate that MSB may improve reproductive performance in aging quails by reshaping the gut microbiota and its metabolite outputs in a manner that supports reproductive endocrine function. Overall, this study provides novel insights supporting the use of microencapsulated sodium butyrate as a functional feed additive for extending the productive lifespan of laying quails.