Scholarlink

<p>Recent outbreaks of Marburg virus disease in regions of sub-Saharan Africa without prior record such as Ghana, Tanzania, Equatorial Guinea, and Rwanda challenge the current understanding of areas at-risk for filovirus spillover. The orthomarburgvirus host <i>Rousettus aegyptiacus</i> exists in these regions, and has a sister species, <i>Rousettus madagascariensis</i>, native only to the island of Madagascar. We expand on previous surveillance of frugivorous bats in Madagascar, and detect seroreactivity against an orthoebolavirus antigenically-related to Bundibugyo virus at 1.50–5.06% seroprevalence in <i>Rousettus madagascariensis</i>. Notably, we identify <i>R. madagascariensis</i> as an orthomarburgvirus-host species of interest in Madagascar, the first record of this virus genus on the island. We document seroprevalences of 15.36–29.78% for Ravn virus and 12.55–33.33% for Marburg virus in <i>R. madagascariensis</i>. These findings will guide future biosurveillance efforts to assess filovirus spillover risk in Madagascar.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Serologic evidence of orthomarburgviruses and an orthoebolavirus in frugivorous Malagasy bats

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月30日

查看全文
  • Marana S. Rekedal,
  • Emily Cornelius Ruhs,
  • Hafaliana Christian Ranaivoson,
  • Neil Mittal,
  • Spencer L. Sterling,
  • Gwenddolen Kettenburg,
  • Angelo Andrianiaina,
  • Santino Andry,
  • Lianying Yan,
  • Axel T. Lehrer,
  • Jean-Michel Héraud,
  • Vincent Lacoste,
  • Philippe Dussart,
  • Cara E. Brook,
  • Eric D. Laing

摘要

Recent outbreaks of Marburg virus disease in regions of sub-Saharan Africa without prior record such as Ghana, Tanzania, Equatorial Guinea, and Rwanda challenge the current understanding of areas at-risk for filovirus spillover. The orthomarburgvirus host Rousettus aegyptiacus exists in these regions, and has a sister species, Rousettus madagascariensis, native only to the island of Madagascar. We expand on previous surveillance of frugivorous bats in Madagascar, and detect seroreactivity against an orthoebolavirus antigenically-related to Bundibugyo virus at 1.50–5.06% seroprevalence in Rousettus madagascariensis. Notably, we identify R. madagascariensis as an orthomarburgvirus-host species of interest in Madagascar, the first record of this virus genus on the island. We document seroprevalences of 15.36–29.78% for Ravn virus and 12.55–33.33% for Marburg virus in R. madagascariensis. These findings will guide future biosurveillance efforts to assess filovirus spillover risk in Madagascar.