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Background <p>Optically pumped magnetometers magnetoencephalography (OPM-MEG) have demonstrated their value in the diagnosis and mapping of epilepsy, as well as their advantages in pediatric applications.</p> Case presentation <p>We present a case of 8-year-old boy with drug-resistant epilepsy, whose epileptogenic lesion is in left Broca’s region. The boy underwent language function evaluation and localization by on-scalp OPM-MEG before surgery. Dipole clusters and Dipole Density of epileptogenic signals by OPM-MEG were located in the left inferior frontal gyrus, though language verbal generation mapping of OPM-MEG signals were mainly located in left frontal orbital gyrus, indicating a localization of the language function area. Seizure freedom and no loss of language function were achieved after MRI-guided laser interstitial thermal therapy.</p> Conclusions <p>This article underscores the feasibility of using OPM-MEG to record abnormal discharges of seizure and assess language function area in children, especially in drug-resistant epilepsy surgery involving brain functional areas.</p>

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Case report: precise mapping and epilepsy surgery of the Broca's area after a comprehensive OPM-MEG investigation of Broca's area localization

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月3日

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  • Yuanfeng Zhou,
  • Yanjiong Zhang,
  • Luo Tian,
  • Tianshuang Wang,
  • Min Wang,
  • Renqing Zhu,
  • Hao Li,
  • Zhongwei Qiao,
  • Zhigang Cao,
  • Yuming Peng,
  • Ming Ding,
  • Yi Wang

摘要

Background

Optically pumped magnetometers magnetoencephalography (OPM-MEG) have demonstrated their value in the diagnosis and mapping of epilepsy, as well as their advantages in pediatric applications.

Case presentation

We present a case of 8-year-old boy with drug-resistant epilepsy, whose epileptogenic lesion is in left Broca’s region. The boy underwent language function evaluation and localization by on-scalp OPM-MEG before surgery. Dipole clusters and Dipole Density of epileptogenic signals by OPM-MEG were located in the left inferior frontal gyrus, though language verbal generation mapping of OPM-MEG signals were mainly located in left frontal orbital gyrus, indicating a localization of the language function area. Seizure freedom and no loss of language function were achieved after MRI-guided laser interstitial thermal therapy.

Conclusions

This article underscores the feasibility of using OPM-MEG to record abnormal discharges of seizure and assess language function area in children, especially in drug-resistant epilepsy surgery involving brain functional areas.