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<p>Potato late blight, caused by the oomycete pathogen <i>Phytophthora infestans</i>, remains one of the most serious threats to global food security. Plants rely on a sophisticated intracellular immune system centered on nucleotide-binding leucine-rich repeat (NLR) receptors to perceive pathogen effectors. However, the rapid evolution of these effectors often renders individual resistance (<i>R</i>) genes ineffective within a short time frame. In a recent study, Wang et al<i>.</i> (Nature, 2025, <a href="https://doi.org/10.1038/s41586-025-09678-5">https://doi.org/10.1038/s41586-025-09678-5</a>) addressed this long-standing challenge by constructing a section-wide NLRome for potato. This comprehensive resource enabled cloning three previously unknown late blight <i>R</i> genes and led to the proposal of a ‘plug-in’ strategy for modular and precision resistance engineering.</p>

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Potato NLRome provides a plug-in blueprint for precision disease resistance engineering

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月15日

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  • Junhyeong Kim,
  • Kee Hoon Sohn

摘要

Potato late blight, caused by the oomycete pathogen Phytophthora infestans, remains one of the most serious threats to global food security. Plants rely on a sophisticated intracellular immune system centered on nucleotide-binding leucine-rich repeat (NLR) receptors to perceive pathogen effectors. However, the rapid evolution of these effectors often renders individual resistance (R) genes ineffective within a short time frame. In a recent study, Wang et al. (Nature, 2025, https://doi.org/10.1038/s41586-025-09678-5) addressed this long-standing challenge by constructing a section-wide NLRome for potato. This comprehensive resource enabled cloning three previously unknown late blight R genes and led to the proposal of a ‘plug-in’ strategy for modular and precision resistance engineering.