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Background <p>Our review assessed whole body (WB) and dedicated body-part magnetic resonance imaging (DedMRI) techniques, protocols, and inflammatory scoring systems, focusing on their clinimetric properties (reliability, validity, responsiveness) in clinical and research settings of patients with juvenile idiopathic inflammatory myopathies (JIIM).</p> Methods <p>A comprehensive search of MEDLINE, EMBASE, and Cochrane databases from 2000 to 2024 identified relevant studies.</p> Results <p>Sixteen studies enrolling JIIM patients with MRI were reviewed, which showed heterogeneity in objectives, methodologies, and scoring systems. Four (25%) studies used quantitative assessments, while 12 (75%) employed semi-quantitative or qualitative methods in scoring MRI. WB-MRI was performed in 3 (18.7%) studies, and DedMRI in 13 (81.2%). Muscle evaluation included assessments of edema [14 (87.5%) studies], fatty infiltration [4 (25%) studies], and atrophy [6 (37.5%) studies]. T1 images were used in 9 (56.2%) studies for measuring chronic changes, with coronal views reported in 6 (37.5%). Fluid-sensitive sequences (T2 with fat saturation, STIR) were employed in all studies and were obtained in the coronal plane in 9 (56.2%). These sequences were crucial for detecting soft tissue edema related to acute/subacute inflammation. One (6%) study included diffusion and T1 post-contrast sequences.</p> Conclusion <p>There is significant heterogeneity in MRI protocols for evaluating JIIM. Standardized WB-MRI protocols are needed to ensure consistency and comparability across studies and institutions, optimize assessments of disease activity, treatment response, and follow-up in JIIM patients. Standardization should enhance the reliability of MRI for diagnosing and monitoring JIIM in clinical and research settings.</p>

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Juvenile idiopathic inflammatory myopathies assessment by magnetic resonance imaging: a scoping review of protocols, scoring systems, and applications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月21日

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  • Vitor Tavares Paula,
  • Clarissa Harumi Omori,
  • Samuel Katsuyuki Shinjo,
  • Daniel Brito de Araújo,
  • Jessica Day,
  • Adam Schiffenbauer,
  • Claudia Saad Magalhães,
  • Edoardo Conticini,
  • Edoardo Marrani,
  • Julio Brandão Guimarães,
  • Lisa G. Rider,
  • Mickael Essouma,
  • Simone Appenzeller,
  • Andrea Schwarz Doria,
  • Adriana Maluf Elias,
  • Jemima Albayda,
  • Nur Azizah Allameen,
  • Tamima Mohamad Abou Arabi,
  • Simone Appenzeller,
  • Iazsmin Bauer-Ventura,
  • Leonardo Calderon,
  • Carla Cappello,
  • Corrado Campochiaro,
  • Lisa Christopher-Stine,
  • Edoardo Conticini,
  • Maryam Dastmalchi,
  • Jessica Alice Day,
  • Daniel de Araujo,
  • Mazen M. Dimachkie,
  • Andrea Schwarz Doria,
  • Adriana Maluf Elias,
  • Mickael Essouma,
  • Brian M Feldman,
  • Daren Gibson,
  • Julio Brandão Guimarães,
  • Kaniah Gunter,
  • Latika Gupta,
  • Shinese Harvey,
  • Adina Kay Knight,
  • John Karpewycz,
  • Eva Kirkhus,
  • Katerina Kubinová,
  • Sean Lanças,
  • Annie Lau-Kilby,
  • James B. Lilleker,
  • Aravi Loganathan,
  • Matteo Lucchini,
  • Pedro M Machado,
  • Claudia Saad-Magalhães,
  • Andrew Mammen,
  • Edoardo Marrani,
  • Arthur Meyers,
  • Siamak Moghadam-Kia,
  • Elie Naddaf,
  • Susan OߣHanlon,
  • Clarissa Harumi Omori,
  • Karen Paddock,
  • Julie J. Paik,
  • Jin Kyun Park,
  • Vitor Tavares Paula,
  • Irene Peralta Garcia,
  • Susan Phaneuf,
  • Jennifer Prendergast,
  • Ann Reed,
  • Bernadette Redd,
  • Lisa G. Rider,
  • Mary Anne Riopel,
  • Dax Rumsey,
  • Sharfaraz Salam,
  • Helga Sanner,
  • Anindita Santosa,
  • Didem Saygin,
  • Adam Schiffenbauer,
  • Avinash Sharma,
  • Susan Shenoi,
  • Samuel Katsuyuki Shinjo,
  • Anrudha Singh,
  • Jennifer Stimec,
  • Narayan Sundaram,
  • Katarzyna Swierkocka,
  • Mirkamal Tolend,
  • Clarissa Carvalho Valões,
  • Anneke J. van der Kooi

摘要

Background

Our review assessed whole body (WB) and dedicated body-part magnetic resonance imaging (DedMRI) techniques, protocols, and inflammatory scoring systems, focusing on their clinimetric properties (reliability, validity, responsiveness) in clinical and research settings of patients with juvenile idiopathic inflammatory myopathies (JIIM).

Methods

A comprehensive search of MEDLINE, EMBASE, and Cochrane databases from 2000 to 2024 identified relevant studies.

Results

Sixteen studies enrolling JIIM patients with MRI were reviewed, which showed heterogeneity in objectives, methodologies, and scoring systems. Four (25%) studies used quantitative assessments, while 12 (75%) employed semi-quantitative or qualitative methods in scoring MRI. WB-MRI was performed in 3 (18.7%) studies, and DedMRI in 13 (81.2%). Muscle evaluation included assessments of edema [14 (87.5%) studies], fatty infiltration [4 (25%) studies], and atrophy [6 (37.5%) studies]. T1 images were used in 9 (56.2%) studies for measuring chronic changes, with coronal views reported in 6 (37.5%). Fluid-sensitive sequences (T2 with fat saturation, STIR) were employed in all studies and were obtained in the coronal plane in 9 (56.2%). These sequences were crucial for detecting soft tissue edema related to acute/subacute inflammation. One (6%) study included diffusion and T1 post-contrast sequences.

Conclusion

There is significant heterogeneity in MRI protocols for evaluating JIIM. Standardized WB-MRI protocols are needed to ensure consistency and comparability across studies and institutions, optimize assessments of disease activity, treatment response, and follow-up in JIIM patients. Standardization should enhance the reliability of MRI for diagnosing and monitoring JIIM in clinical and research settings.