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<p>Fibromyalgia is a complex condition characterized by widespread chronic pain, fatigue, and sleep disturbances, which significantly affect quality of life. Its pathophysiology involves central sensitization (CS) and changes in neurotransmitters. Management is challenging and requires a multidisciplinary approach that integrates pharmacological and nonpharmacological treatments. This consensus, which is based on the BASCE system, presents updated guidelines for drug and nondrug treatments. The methodology focused on the evaluation of meta-analyses and systematic reviews of the literature and on voting by experts from the Brazilian Society of Rheumatology, ensuring recommendations with at least 70% agreement. Divided into two articles, this article addresses pharmacological strategies, incorporating recent advances to optimize clinical management and promote uniformity in professional practice.</p>

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Review of fibromyalgia treatment guidelines: part 2 – pharmacological treatment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月22日

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  • Roberto Ezequiel Heymann,
  • Marcelo Cruz Rezende,
  • Eduardo dos Santos Paiva,
  • Marcos Renato de Assis,
  • Alessandra de Sousa Braz,
  • Aline Ranzolin,
  • Ana Paula Monteiro Gomides Reis,
  • Andrea Pimentel Fonseca Golmia,
  • Anna Beatriz Assad Maia,
  • Denison Santos Silva,
  • Fernando Augusto Chiuchetta,
  • Gabriela Galassi,
  • Izabela Guimarães,
  • José Eduardo Martinez,
  • José Roberto Provenza,
  • Juliana Maria de Freitas Trindade Costa,
  • Marcos Paulo Veloso Correia,
  • Marco Antônio Gonçalves Pontes Filho,
  • Marco Aurelio Goldenfum,
  • Marcos Aurelio de Freitas Machado,
  • Melissa Mariti Fraga,
  • Nilton Salles Rosa Neto,
  • Rafael Navarrete Fernandez

摘要

Fibromyalgia is a complex condition characterized by widespread chronic pain, fatigue, and sleep disturbances, which significantly affect quality of life. Its pathophysiology involves central sensitization (CS) and changes in neurotransmitters. Management is challenging and requires a multidisciplinary approach that integrates pharmacological and nonpharmacological treatments. This consensus, which is based on the BASCE system, presents updated guidelines for drug and nondrug treatments. The methodology focused on the evaluation of meta-analyses and systematic reviews of the literature and on voting by experts from the Brazilian Society of Rheumatology, ensuring recommendations with at least 70% agreement. Divided into two articles, this article addresses pharmacological strategies, incorporating recent advances to optimize clinical management and promote uniformity in professional practice.