What is known about the effects of vitamin D in neuropsychiatric lupus?

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2024年1月2日

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Thaís Evelyn Karnopp,
Vinicius da Silva Freitas,
Andressa Leite Di Domenico,
Gustavo Flores Chapacais,
Natália Garcia dos Santos,
Eduarda Correa Freitas,
Andrese Aline Gasparin,
Odirlei André Monticielo

摘要

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect several organs and systems. The central and/or peripheral nervous system can suffer from complications known as neuropsychiatric lupus (NPSLE). Studies have associated the manifestations of SLE or NPSLE with vitamin D deficiency. It has been shown that hypovitaminosis D can lead to cognition deficits and cerebral hypoperfusion in patients with NPSLE. In this review article, we will address the main features related to vitamin D supplementation or serum vitamin D levels with neuropsychiatric manifestations, either in patients or in animal models of NPSLE.

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