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Background <p>Mpox, caused by the Mpox virus, is a zoonotic disease historically endemic in Central and West Africa. Despite the Democratic Republic of Congo (DRC) carrying the highest Mpox burden, the literature lacks comprehensive data on long-term trends and geographic disparities inMpox% disease severity and mortality, highlighting a significant research gap. Understanding severity and mortality trends is critical for global control efforts.</p> Methods <p>This systematic review and meta-analysis followed PRISMA guidelines to synthesize evidence on Mpox severity and mortality in the DRC from 1970 to 2024. We searched PubMed, ScienceDirect, Scopus, Web of Science. Random-effects models addressed high heterogeneity, and subgroup analyses examined temporal trends, regional differences, and healthcare settings. Meta-regression explored sources of heterogeneity for both severity and case fatality rate, adjusting for study year, region, and setting.</p> Results <p>We included a total of 19 study reports. The pooled severity rate among 3,280 confirmed cases was 39.47% (95% confidence interval [CI] 29.11–50.86). Case fatality rates (CFRs) were 1.70% (95% CI 0.72–3.95) among 3152 suspected cases and 2.46% (95% CI 0.65–8.85) for 2239 confirmed cases. Meta-regression revealed that study year, region and setting were significant sources of heterogeneity of case fatality rates among confirmed mpox cases.</p> Conclusion <p>Mpox continues to impose a substantial burden in the DRC, with a high severity and moderate mortality rates. Targeted interventions, including vaccination in high-risk areas, community education, and healthcare system strengthening are warranted.</p>

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Mpox severity and mortality in the DRC: a systematic review and meta-analysis (1970–2024)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月1日

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  • Fabrice Zobel Lekeumo Cheuyem,
  • Armel Zemsi,
  • Jonathan Hangi Ndungo,
  • Chabeja Achangwa,
  • Davy Roméo Takpando-Le-Grand,
  • Jessy Goupeyou-Youmsi,
  • Solange Dabou,
  • Mohamadou Adama,
  • Ariane Nouko,
  • Marie Angèle Mbang,
  • Edwige Omona Guissana,
  • Rick Tchamani,
  • Vanessa Monique Mballa Assiene,
  • Ethel Ambo Eno,
  • Constantine Tanywe Asahngwa,
  • Saralees Nadarajah

摘要

Background

Mpox, caused by the Mpox virus, is a zoonotic disease historically endemic in Central and West Africa. Despite the Democratic Republic of Congo (DRC) carrying the highest Mpox burden, the literature lacks comprehensive data on long-term trends and geographic disparities inMpox% disease severity and mortality, highlighting a significant research gap. Understanding severity and mortality trends is critical for global control efforts.

Methods

This systematic review and meta-analysis followed PRISMA guidelines to synthesize evidence on Mpox severity and mortality in the DRC from 1970 to 2024. We searched PubMed, ScienceDirect, Scopus, Web of Science. Random-effects models addressed high heterogeneity, and subgroup analyses examined temporal trends, regional differences, and healthcare settings. Meta-regression explored sources of heterogeneity for both severity and case fatality rate, adjusting for study year, region, and setting.

Results

We included a total of 19 study reports. The pooled severity rate among 3,280 confirmed cases was 39.47% (95% confidence interval [CI] 29.11–50.86). Case fatality rates (CFRs) were 1.70% (95% CI 0.72–3.95) among 3152 suspected cases and 2.46% (95% CI 0.65–8.85) for 2239 confirmed cases. Meta-regression revealed that study year, region and setting were significant sources of heterogeneity of case fatality rates among confirmed mpox cases.

Conclusion

Mpox continues to impose a substantial burden in the DRC, with a high severity and moderate mortality rates. Targeted interventions, including vaccination in high-risk areas, community education, and healthcare system strengthening are warranted.