Scholarlink

Background and purpose <p>The glycation process produces a great deal of free radicals during its initial and propagation phases. It also produces carbonyl species and reactive dicarbonyl species, the most reactive of which is methylglyoxal (MG), which may trigger dicarbonyl stress and interfere with regular bodily functions. In the advanced stage, oxidative stress, inflammatory response, and chronic illnesses are thought to be caused due to the generation of AGEs (advanced glycation end products) and the interaction between AGEs and their receptor, RAGE (Receptor advanced glycation end products). AGE-RAGE interaction, eventually results in the production of reactive oxygen species (ROS) that causes stimulation of its downstream signaling pathways, including nuclear factor (NF)-kB and phosphoinositide 3-kinase\ (protein kinase B / (PI3K)/Akt. All these products play a significant role in several metabolic disorders including diabetes and carcinogenesis. The properties of polyphenols as inhibitors of AGEs formation and AGE-RAGE interaction have garnered a lot of attention from scholars. This study enumerates the process of glycation, glycation in cancer and antiglycation activities of polyphenols to combat cancer.</p> Methods <p>Various studies on AGE-RAGE interaction in cancers on PubMed and Science direct searches were collected which authenticated glycation as one of the reasons of cancer development and the role of polyphenols in inhibition of glycation, accumulation of AGEs and interaction between AGE and RAGE to form ROS and thus prevent the initiation and development of tumour.</p> Results <p>In this review, the focus was on the generation of AGEs, interaction between AGE and RAGE and signaling pathways activation that result in cancer. Interestingly, polyphenols mediated inhibition of AGEs formation and their interaction with RAGE was envisioned.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Role of polyphenols in modulating AGEs-RAGE axis in cancer, a review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月28日

查看全文
  • Ritu Raina,
  • P. S. K. Sanjana,
  • Saleha Mohammed Razaulla,
  • Ravinder Bhatt,
  • Arif Hussain

摘要

Background and purpose

The glycation process produces a great deal of free radicals during its initial and propagation phases. It also produces carbonyl species and reactive dicarbonyl species, the most reactive of which is methylglyoxal (MG), which may trigger dicarbonyl stress and interfere with regular bodily functions. In the advanced stage, oxidative stress, inflammatory response, and chronic illnesses are thought to be caused due to the generation of AGEs (advanced glycation end products) and the interaction between AGEs and their receptor, RAGE (Receptor advanced glycation end products). AGE-RAGE interaction, eventually results in the production of reactive oxygen species (ROS) that causes stimulation of its downstream signaling pathways, including nuclear factor (NF)-kB and phosphoinositide 3-kinase\ (protein kinase B / (PI3K)/Akt. All these products play a significant role in several metabolic disorders including diabetes and carcinogenesis. The properties of polyphenols as inhibitors of AGEs formation and AGE-RAGE interaction have garnered a lot of attention from scholars. This study enumerates the process of glycation, glycation in cancer and antiglycation activities of polyphenols to combat cancer.

Methods

Various studies on AGE-RAGE interaction in cancers on PubMed and Science direct searches were collected which authenticated glycation as one of the reasons of cancer development and the role of polyphenols in inhibition of glycation, accumulation of AGEs and interaction between AGE and RAGE to form ROS and thus prevent the initiation and development of tumour.

Results

In this review, the focus was on the generation of AGEs, interaction between AGE and RAGE and signaling pathways activation that result in cancer. Interestingly, polyphenols mediated inhibition of AGEs formation and their interaction with RAGE was envisioned.