Background <p>Iatrogenic superior gluteal artery injury (SGA) following bone marrow biopsy is rare but potentially life-threatening. Due to the deep intrapelvic location of the vessel, conventional management with manual compression or surgical repair is challenging. Traditional management via endovascular coil embolization requires arterial access and vessel sacrifice.</p> <p>Case presentation</p> <p>We present a case of SGA injury resulting from a bone marrow biopsy in a patient with suspected T-cell lymphoma. The injury was successfully managed using a 6 french Angioseal closure device applied directly through the biopsy puncture site in the gluteal region, with the patient maintained in the lateral decubitus position. The approach achieved immediate hemostasis while preserving arterial patency.</p> Conclusion <p>This represents the first reported use of an Angioseal device for direct percutaneous treatment of iatrogenic SGA injury. This technique offers an effective hemostasis and vessel preservation, expanding the interventional radiology’s armamentarium.</p> Graphical Abstract <p></p>