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<p>Astroblastoma is a rare tumor with an uncertain origin, primarily affecting children or young adults. A 10-year-old girl experienced headache and vomiting. Contrast-enhanced MRI revealed a well-defined cortical-subcortical mass in the left parietal lobe. Histological analysis confirmed the diagnosis of astroblastoma. Immunohistochemical staining showed that tumor cells were positive for GFAP, S-100, Vimentin, and focally for EMA, but negative for Synaptophysin, SALL-4, and CD117. On further analysis there was gain of chromosome 19 and MN1 alteration was&#xa0;noted.</p>

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Astroblastoma: an emerging differential!!

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月20日

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  • Yashita Gupta,
  • Aishwarya John,
  • Sweety G. Merlin

摘要

Astroblastoma is a rare tumor with an uncertain origin, primarily affecting children or young adults. A 10-year-old girl experienced headache and vomiting. Contrast-enhanced MRI revealed a well-defined cortical-subcortical mass in the left parietal lobe. Histological analysis confirmed the diagnosis of astroblastoma. Immunohistochemical staining showed that tumor cells were positive for GFAP, S-100, Vimentin, and focally for EMA, but negative for Synaptophysin, SALL-4, and CD117. On further analysis there was gain of chromosome 19 and MN1 alteration was noted.