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Background <p>Breast leiomyoma is a rare neoplasm, accounting for less than 1% of all breast neoplasms. Most of the leiomyomas occur in the subareolar region. There are a few reported cases of intraparenchymal leiomyoma. Rarely reported, cases of intraparenchymal leiomyoma with atypical features are not a well-defined entity, and little is known about their clinical course.</p> Case presentation <p>We present a rare case report of breast parenchymal leiomyoma in a 45-year-old woman. The clinical characteristics, imaging findings, and histology of the lesion are discussed here. Atypical morphological features observed in this case were focal atypia, increased mitosis, and Ki-67 proliferation index.</p> Conclusion <p>In the absence of a well-defined diagnostic criteria, the exact behavior of parenchymal leiomyoma with atypical features is difficult to ascertain. These cases should be closely followed after wide local excision.</p>

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“Intraparenchymal leiomyoma of breast with atypical features: diagnostic dilemma”

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月20日

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  • Amber Parwaiz,
  • Avinash Singh,
  • Tarun Kumar,
  • Punam Bhadani

摘要

Background

Breast leiomyoma is a rare neoplasm, accounting for less than 1% of all breast neoplasms. Most of the leiomyomas occur in the subareolar region. There are a few reported cases of intraparenchymal leiomyoma. Rarely reported, cases of intraparenchymal leiomyoma with atypical features are not a well-defined entity, and little is known about their clinical course.

Case presentation

We present a rare case report of breast parenchymal leiomyoma in a 45-year-old woman. The clinical characteristics, imaging findings, and histology of the lesion are discussed here. Atypical morphological features observed in this case were focal atypia, increased mitosis, and Ki-67 proliferation index.

Conclusion

In the absence of a well-defined diagnostic criteria, the exact behavior of parenchymal leiomyoma with atypical features is difficult to ascertain. These cases should be closely followed after wide local excision.