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Background <p>Merkel cell carcinoma is a very rare and aggressive primary cutaneous neuroendocrine carcinoma with rapid growth and a risk of early metastasis and regional recurrence despite treatment.</p> Main body <p>This review covers the diagnostic and staging process for Merkel cell carcinoma, from preanalytical clinical reporting and biopsy selection to gross examination and essential histopathological findings for accurate diagnosis.</p> Conclusion <p>Understanding the necessary steps for a definitive diagnosis, beginning with the appropriate biopsy type, detailed clinical reporting, proper processing and handling of specimens, and thorough gross and microscopic evaluation, is crucial for all clinicians and pathologists, leading to accurate diagnosis and staging.</p>

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Merkel cell carcinoma: a review from the preanalytical to the postanalytical phase by the Brazilian society of pathology

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月20日

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  • Annelise de Almeida Verdolin,
  • Emilio Augusto Campos Pereira de Assis,
  • Ana Letícia Boff,
  • Karina Munhoz de Paula Alves Coelho,
  • Robledo Fonseca Rocha

摘要

Background

Merkel cell carcinoma is a very rare and aggressive primary cutaneous neuroendocrine carcinoma with rapid growth and a risk of early metastasis and regional recurrence despite treatment.

Main body

This review covers the diagnostic and staging process for Merkel cell carcinoma, from preanalytical clinical reporting and biopsy selection to gross examination and essential histopathological findings for accurate diagnosis.

Conclusion

Understanding the necessary steps for a definitive diagnosis, beginning with the appropriate biopsy type, detailed clinical reporting, proper processing and handling of specimens, and thorough gross and microscopic evaluation, is crucial for all clinicians and pathologists, leading to accurate diagnosis and staging.