<p>The experimental study conducted by Taşkın et al. aimed to study the cellular responses in brain tissues after the direct implantation of a platinum coil, simulating the protrusion of a coil in endovascular aneurysm treatment. The study offers valuable insights into the interactions between tissues and coils, but some limitations should be noted when interpreting the results. The study has some limitations, with the direct implantation of the platinum coil in brain tissues not simulating the intravascular environment where the protrusion of the coil actually happens. The study’s conclusions on the risk of thromboembolism and lack of irritation in tissues may be overemphasized, as this study did not include the blood flow dynamics, control groups, and immunohistochemical characterization. Past experimental and histopathological studies have shown that intraluminal processes, which include blood, coil, and blood vessel wall interactions, are primarily responsible for aneurysm healing and thromboembolic complications. The authors should be commended on their novel study, but the results should be viewed with some reservation when interpreting the study’s conclusions in a clinical context. Further clarifying this may help the reader better comprehend the study’s findings.</p>