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Background <p>Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Although treatment and rehabilitation have improved, more effective therapies are still needed. Stem cell therapy has emerged as a promising option. This review examines its potential benefits in TBI management.</p> Methods <p>A systematic review was conducted following Cochrane and Reporting Items for Systematic Reviews and Meta-Analyses—PRISMA 2020 guidelines. PubMed was searched using the terms “traumatic brain injury,” “stem cells,” and “treatment.” Studies assessing the effects of stem cells on neurological function in TBI patients were included.</p> Results <p>After analyzing 1092 publications, only two studies met the inclusion criteria. Both showed promising preliminary results with the use of stem cells in the treatment of traumatic brain injury (TBI), both in acute and chronic phases. However, the evidence base is too limited to draw definitive conclusions.</p> Conclusions <p>Stem cell–based therapies may hold promise for TBI, but current evidence remains limited. Larger, well-designed studies are needed to confirm efficacy and safety.</p>

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Stem cells in the treatment of traumatic brain injury: a systematic review of the literature

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月23日

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  • Julián D. Laguna-Cuellar,
  • Luna Silva-Varela,
  • Sebastian Rojas-Tovar,
  • José D. Charry

摘要

Background

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Although treatment and rehabilitation have improved, more effective therapies are still needed. Stem cell therapy has emerged as a promising option. This review examines its potential benefits in TBI management.

Methods

A systematic review was conducted following Cochrane and Reporting Items for Systematic Reviews and Meta-Analyses—PRISMA 2020 guidelines. PubMed was searched using the terms “traumatic brain injury,” “stem cells,” and “treatment.” Studies assessing the effects of stem cells on neurological function in TBI patients were included.

Results

After analyzing 1092 publications, only two studies met the inclusion criteria. Both showed promising preliminary results with the use of stem cells in the treatment of traumatic brain injury (TBI), both in acute and chronic phases. However, the evidence base is too limited to draw definitive conclusions.

Conclusions

Stem cell–based therapies may hold promise for TBI, but current evidence remains limited. Larger, well-designed studies are needed to confirm efficacy and safety.