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Background <p>Hopkins syndrome (HS) is a rare neuromuscular disorder characterized by poliomyelitis-like flaccid paralysis occurring in children after an acute asthma attack. This report describes the multimodal neurophysiological and ultrasonographic evaluation of a child presenting with post-asthmatic lower limb weakness and discusses the differential diagnosis of flaccid paralysis in childhood.</p> Case presentation <p>A 2-year-old boy presented with left leg weakness two weeks after an asthma exacerbation; one month after symptom onset, he was unable to walk without assistance. The child’s past medical history was significant only for asthma, and his vaccination schedule, including for poliomyelitis, was up to date. Neurological examination revealed left lower limb weakness with areflexia (absent reflexes) and moderate atrophy. Electroneuromyography and muscle ultrasound indicated a chronic, asymmetric anterior horn cell disease without evidence of acute denervation.</p> Conclusion <p>HS is a rare neuromuscular disorder characterized by poliomyelitis-like paralysis that occurs in children following an acute asthma attack. Given its rarity, the pathophysiology and optimal management strategies for HS remain poorly understood. A multimodal assessment combining ultrasound and neurophysiological studies is valuable for improving the characterization of this phenotype.</p>

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Multimodal neurophysiological and ultrasound evaluation in Hopkins syndrome: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月11日

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  • Antonio Edvan Camelo-Filho,
  • Rodrigo Fagundes da Rosa,
  • Pedro Lucas Grangeiro Sá Barreto Lima,
  • Sabrina Soares Timbó,
  • Amanda Camelo Paulino,
  • Maria Luiza Miranda Carneiro,
  • François Loiola Ponte de Souza,
  • Pedro Braga-Neto,
  • Paulo Ribeiro Nóbrega,
  • André Luiz Santos Pessoa

摘要

Background

Hopkins syndrome (HS) is a rare neuromuscular disorder characterized by poliomyelitis-like flaccid paralysis occurring in children after an acute asthma attack. This report describes the multimodal neurophysiological and ultrasonographic evaluation of a child presenting with post-asthmatic lower limb weakness and discusses the differential diagnosis of flaccid paralysis in childhood.

Case presentation

A 2-year-old boy presented with left leg weakness two weeks after an asthma exacerbation; one month after symptom onset, he was unable to walk without assistance. The child’s past medical history was significant only for asthma, and his vaccination schedule, including for poliomyelitis, was up to date. Neurological examination revealed left lower limb weakness with areflexia (absent reflexes) and moderate atrophy. Electroneuromyography and muscle ultrasound indicated a chronic, asymmetric anterior horn cell disease without evidence of acute denervation.

Conclusion

HS is a rare neuromuscular disorder characterized by poliomyelitis-like paralysis that occurs in children following an acute asthma attack. Given its rarity, the pathophysiology and optimal management strategies for HS remain poorly understood. A multimodal assessment combining ultrasound and neurophysiological studies is valuable for improving the characterization of this phenotype.