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Objective <p>We evaluate the clinical and radiological features, as well as the outcomes, of neurological disorders associated with scrub typhus.</p> Methods <p>This is a retrospective, cross-sectional study from South India, from January 2020 to January 2023. Patients presented with meningoencephalitis, cerebellitis, rhombencephalitis, vasculitis, and opsoclonus myoclonus ataxia syndrome (OMAS). A late complication of polyradiculopathy was also observed. The investigations included cerebrospinal fluid (CSF) examination and magnetic resonance imaging (MRI) brain.</p> Results <p>Seventeen patients with scrub typhus-associated neurological disorders were included, with a mean age of 31.6 ± 13.1&#xa0;years, and two-thirds were males. The majority of patients had lymphocytic pleocytosis in CSF and raised protein. Brain MRI changes included meningeal enhancement, acute infarcts, and alterations in the brainstem and cerebellum. All patients received doxycycline and the majority showed improvement at follow-up.</p> Conclusion <p>Scrub typhus-associated neurological disorders commonly present as meningitis, encephalitis, or meningoencephalitis, with lymphocytic pleocytosis and raised protein in CSF. We expand the spectrum to include CNS vasculitis- like picture, rhombencephalitis, OMAS and a hitherto unreported late complication of polyradiculopathy. Early diagnosis and prompt treatment with doxycycline and supportive care can lead to favorable outcomes.</p>

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Clinico-radiological spectrum of neurological involvement in scrub typhus: insights from 17 cases at a Quaternary Care Centre

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月24日

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  • Farhan Mohammed Ansari,
  • Sahil Mathur,
  • Debayan Dutta,
  • Nikhilesh Pradhan,
  • Maherafsha Hundekari,
  • Seena Vengalil,
  • Pooja Mailankody,
  • Girish Baburao Kulkarni,
  • Saraswati Nashi,
  • Faheem Arshad,
  • S. Nagarathna,
  • Karthik Kulanthaivelu

摘要

Objective

We evaluate the clinical and radiological features, as well as the outcomes, of neurological disorders associated with scrub typhus.

Methods

This is a retrospective, cross-sectional study from South India, from January 2020 to January 2023. Patients presented with meningoencephalitis, cerebellitis, rhombencephalitis, vasculitis, and opsoclonus myoclonus ataxia syndrome (OMAS). A late complication of polyradiculopathy was also observed. The investigations included cerebrospinal fluid (CSF) examination and magnetic resonance imaging (MRI) brain.

Results

Seventeen patients with scrub typhus-associated neurological disorders were included, with a mean age of 31.6 ± 13.1 years, and two-thirds were males. The majority of patients had lymphocytic pleocytosis in CSF and raised protein. Brain MRI changes included meningeal enhancement, acute infarcts, and alterations in the brainstem and cerebellum. All patients received doxycycline and the majority showed improvement at follow-up.

Conclusion

Scrub typhus-associated neurological disorders commonly present as meningitis, encephalitis, or meningoencephalitis, with lymphocytic pleocytosis and raised protein in CSF. We expand the spectrum to include CNS vasculitis- like picture, rhombencephalitis, OMAS and a hitherto unreported late complication of polyradiculopathy. Early diagnosis and prompt treatment with doxycycline and supportive care can lead to favorable outcomes.