Scholarlink

Background and purpose <p>To provide basic background knowledge about spinal excitability in functional “nonspecific” CLBP patients, we aim to investigate the H-reflex, F-wave, and SEP in these patients. This information will be useful when developing specific neurorehabilitation programs to modulate the pathological changes in spinal excitability that promote pain transmission in these patients. Additionally, we want to evaluate the effects of pain and psychiatric comorbidities in functioning CLBP patients.</p> Methods <p>For this purpose, a case control study was designed and Fifty Patients were recruited from Neuropsychiatric outpatient clinic at Sohag University Hospital complaining of functional CLBP for more than 12 Weeks out of a hundred and fifty patients who came to our outpatient clinic during duration of the study suffering from CLBP. The fifty patients included in the study didn’t suffer from any local cause that could explain their CLBP and all had normal MRI lumbosacral spine. Another fifty Healthy volunteers included in the control group of the study were recruited from our Neuropsychiatric outpatient Clinic. Routine NCS were performed on both cases and controls to exclude from any disease that could affect the results and interpretation of the parameters of the H-reflex, F-wave or SEP, including polyneuropathy, then H-reflex, F-wave and SEP (Latency of P40) were performed on both patients and controls. The score on a visual analogue scale (VAS) for pain severity were measured in patients with CLBP only. In addition, Arabic validated versions of the Beck depression inventory and Taylor’s Manifest Anxiety Scale (TMAS) filled by patients and controls were used to measure depression and anxiety in both patients and healthy controls.</p> Results <p>Tibial H-max amplitude was significantly lower in cases than in controls as well as the Tibial M-max amplitude was significantly lower in cases than in controls. The Tibial Hmax/Mmax ratio was significantly lower in cases Than in controls. Psychiatric comorbidities did differ significantly between the two groups with patients with functional CLBP suffering more depression and anxiety compared with healthy controls.</p> Conclusion <p>We discovered that individuals with functional CLBP had a reduced Hmax/Mmax ratio. This suggests that there may be a reduction in spinal excitability in these patients, regardless of other potential pathophysiological variables. We also found higher rates of depression and anxiety in patient with functional CLBP.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Neurophysiological assessment of spinal excitability in chronic low back pain: a case-control study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月26日

查看全文
  • Mohammed N. Thabet,
  • Gharib Fawi,
  • Mahmoud Kamel Khalaf,
  • Ahmed Borai Ahmed

摘要

Background and purpose

To provide basic background knowledge about spinal excitability in functional “nonspecific” CLBP patients, we aim to investigate the H-reflex, F-wave, and SEP in these patients. This information will be useful when developing specific neurorehabilitation programs to modulate the pathological changes in spinal excitability that promote pain transmission in these patients. Additionally, we want to evaluate the effects of pain and psychiatric comorbidities in functioning CLBP patients.

Methods

For this purpose, a case control study was designed and Fifty Patients were recruited from Neuropsychiatric outpatient clinic at Sohag University Hospital complaining of functional CLBP for more than 12 Weeks out of a hundred and fifty patients who came to our outpatient clinic during duration of the study suffering from CLBP. The fifty patients included in the study didn’t suffer from any local cause that could explain their CLBP and all had normal MRI lumbosacral spine. Another fifty Healthy volunteers included in the control group of the study were recruited from our Neuropsychiatric outpatient Clinic. Routine NCS were performed on both cases and controls to exclude from any disease that could affect the results and interpretation of the parameters of the H-reflex, F-wave or SEP, including polyneuropathy, then H-reflex, F-wave and SEP (Latency of P40) were performed on both patients and controls. The score on a visual analogue scale (VAS) for pain severity were measured in patients with CLBP only. In addition, Arabic validated versions of the Beck depression inventory and Taylor’s Manifest Anxiety Scale (TMAS) filled by patients and controls were used to measure depression and anxiety in both patients and healthy controls.

Results

Tibial H-max amplitude was significantly lower in cases than in controls as well as the Tibial M-max amplitude was significantly lower in cases than in controls. The Tibial Hmax/Mmax ratio was significantly lower in cases Than in controls. Psychiatric comorbidities did differ significantly between the two groups with patients with functional CLBP suffering more depression and anxiety compared with healthy controls.

Conclusion

We discovered that individuals with functional CLBP had a reduced Hmax/Mmax ratio. This suggests that there may be a reduction in spinal excitability in these patients, regardless of other potential pathophysiological variables. We also found higher rates of depression and anxiety in patient with functional CLBP.