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Background <p>It is essential to develop novel biomarkers for multiple sclerosis (MS) in order to predict the progression of the disease. This research aims to investigate MS patients’ blood lactate, iron, and lipid profiles as correlates of the extent and progression of the disease. This study included 30 people with secondary progressive MS (SPMS) and 30 people with relapsing-remitting MS (RRMS). Serum lactate, iron, and lipid markers were measured.</p> Results <p>In comparison to RRMS patients, patients with SPMS exhibited a significant decrease in serum High-Density Lipoprotein (HDL) and a significant increase in serum levels of lactate, lipid markers (Total Cholesterol, Triglycerides, and LDL), and iron markers (ferritin and transferrin). The serum levels of HDL and TIBC exhibited a substantial negative correlation with EDSS scores.</p> Conclusion <p>The severity and progression of MS may be correlated with changes in the serum levels of iron, lipid, and lactate indicators. serum lactate, ferritin, and triglycerides can be used as correlates of disease severity.</p>

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Serum lactate, lipids, iron markers as correlates of disease stage and disability in Egyptian multiple sclerosis patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月16日

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  • Shaimaa Shaheen Mohammed,
  • Ebtesam Mohamed Fahmy,
  • Laila Ahmed Rashed,
  • Hanan Helmy,
  • Rania Shehata Ismail,
  • Nahla Merghany,
  • Osama Yacoub

摘要

Background

It is essential to develop novel biomarkers for multiple sclerosis (MS) in order to predict the progression of the disease. This research aims to investigate MS patients’ blood lactate, iron, and lipid profiles as correlates of the extent and progression of the disease. This study included 30 people with secondary progressive MS (SPMS) and 30 people with relapsing-remitting MS (RRMS). Serum lactate, iron, and lipid markers were measured.

Results

In comparison to RRMS patients, patients with SPMS exhibited a significant decrease in serum High-Density Lipoprotein (HDL) and a significant increase in serum levels of lactate, lipid markers (Total Cholesterol, Triglycerides, and LDL), and iron markers (ferritin and transferrin). The serum levels of HDL and TIBC exhibited a substantial negative correlation with EDSS scores.

Conclusion

The severity and progression of MS may be correlated with changes in the serum levels of iron, lipid, and lactate indicators. serum lactate, ferritin, and triglycerides can be used as correlates of disease severity.