Background <p>Sufficient knowledge about post-operative cognitive dysfunction (POCD) may contribute to its early identification and appropriate management. This work aimed to evaluate Egyptian doctors’ awareness of POCD.</p> Results <p>This cross-sectional study was conducted on 337 participants (192 males and 145 females) with a median age of 33 (29–38.5) years. Most of the participants thought that the risk of POCD is higher following open-heart surgeries. They also reported that POCD may be transient or permanent. The majority of participants addressed general anaesthesia as the type of anaesthesia most often incriminated in causing POCD. Also, most of the participants thought that POCD is related to the type and duration of surgery, anesthesia, pre-operative factors, and post-operative complications. The majority of anesthesiologists thought that the following precautions could protect patients from POCD: avoiding inta-operative hypoxia, hypoglycemia, or hypoperfusion (98.5%), multimodal analgesia (91.0%), using drugs such as ketamine, dexmedetomidine, melatonin, or neostigmine (58.2%), good post-operative analgesia (85.1%), and avoiding the use of anticholinergic drugs or benzodiazepines (86.6%).</p> Conclusion <p>Egyptian physicians have relatively good knowledge about the incidence and risk factors of POCD.</p>