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Background <p>Stroke represents the second most common cause of death worldwide and a significant cause of long-term morbidity. Although the brain is incapable of regeneration, the element selenium (Se) has been found to have a role in regenerating the antioxidant systems and improving cell proliferation and viability. So, we conduct this systematic review and meta-analysis to assess its effectiveness in enhancing cell proliferation and viability.</p> Aims <p>Our study aims to determine the efficacy and safety of selenium in alleviating the impact of brain injury and promoting recovery in patients with stroke.</p> Summary of review <p>We finally included five randomized clinical trials. Our meta-analysis showed a statistically significant difference between selenium and placebo in the outcomes of interest: Glasgow Outcome Scale after 1&#xa0;month (OR: 1.54, 95% CI [1.10, 2.15], <i>P</i> = 0.01) and respiratory infection (OR: 0.55, 95% CI [0.34, 0.88], <i>P</i> = 0.01). There is no statistically significant difference in Glasgow Outcome Scale after 3&#xa0;months (OR: 1.36, 95% CI [0.97, 1.91], <i>P</i> = 0.07), mortality (OR: 0.76, 95% CI [0.45, 1.30], <i>P</i> = 0.31).</p> Conclusion <p>Selenium showed a promising contribution to minimizing the damage caused by brain injuries. Further studies, including randomized-controlled trials, must be conducted on the efficacy of selenium and its association with better neurological outcomes.</p>

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Safety and efficacy of selenium in improving the outcomes of stroke patients: a systematic review and meta-analysis with GRADE system

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月6日

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  • Esraa Y. Salama,
  • Mariam A. Shaltout,
  • Rahma Abdelaziz Ismail,
  • Eslam Afifi,
  • Rana Abdelnasser A. Azab,
  • Abdelrahman Abdelshafi,
  • Rahma Sameh Shaheen

摘要

Background

Stroke represents the second most common cause of death worldwide and a significant cause of long-term morbidity. Although the brain is incapable of regeneration, the element selenium (Se) has been found to have a role in regenerating the antioxidant systems and improving cell proliferation and viability. So, we conduct this systematic review and meta-analysis to assess its effectiveness in enhancing cell proliferation and viability.

Aims

Our study aims to determine the efficacy and safety of selenium in alleviating the impact of brain injury and promoting recovery in patients with stroke.

Summary of review

We finally included five randomized clinical trials. Our meta-analysis showed a statistically significant difference between selenium and placebo in the outcomes of interest: Glasgow Outcome Scale after 1 month (OR: 1.54, 95% CI [1.10, 2.15], P = 0.01) and respiratory infection (OR: 0.55, 95% CI [0.34, 0.88], P = 0.01). There is no statistically significant difference in Glasgow Outcome Scale after 3 months (OR: 1.36, 95% CI [0.97, 1.91], P = 0.07), mortality (OR: 0.76, 95% CI [0.45, 1.30], P = 0.31).

Conclusion

Selenium showed a promising contribution to minimizing the damage caused by brain injuries. Further studies, including randomized-controlled trials, must be conducted on the efficacy of selenium and its association with better neurological outcomes.