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Background <p>Symptomatic drop metastases from cerebral oligodendroglioma to the spinal axis or cerebellopontine angle (CPA) are exceedingly rare. While DICER1 mutations are linked to tumor invasion and metastasis across multiple cancers, their roles in oligodendroglioma remains undocumented.</p> Case presentation <p>We describe a recurrent oligodendroglioma with CPA and spinal canal metastases, featuring 1p/19q co-deletion, IDH1 R132H, DICER1 D527Y, TERT promoter mutations, and a novel DICER1 D527Y mutation.</p> Conclusion <p>Symptomatic oligodendroglioma metastases to CPA and spinal regions are rare and correlate with poor prognosis. The identified DICER1 mutation may represent a novel mechanism underlying drop metastases in this tumor type.</p>

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Symptomatic drop metastases to the spinal canal and cerebellopontine angle from cerebral oligodendroglioma with DICER1 mutation: a case report and literature review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月7日

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  • Kai Wang,
  • Haiping Li,
  • Guoqing Zhou,
  • Hongsheng Ji,
  • Yingchao Liu,
  • Shangchen Xu,
  • Tao Song,
  • Bin Liu

摘要

Background

Symptomatic drop metastases from cerebral oligodendroglioma to the spinal axis or cerebellopontine angle (CPA) are exceedingly rare. While DICER1 mutations are linked to tumor invasion and metastasis across multiple cancers, their roles in oligodendroglioma remains undocumented.

Case presentation

We describe a recurrent oligodendroglioma with CPA and spinal canal metastases, featuring 1p/19q co-deletion, IDH1 R132H, DICER1 D527Y, TERT promoter mutations, and a novel DICER1 D527Y mutation.

Conclusion

Symptomatic oligodendroglioma metastases to CPA and spinal regions are rare and correlate with poor prognosis. The identified DICER1 mutation may represent a novel mechanism underlying drop metastases in this tumor type.