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Background <p>Polycystic ovarian syndrome (PCOS) is a gynaecological disorder associated with complex metabolic and endocrine disruptions in the reproductive aged women worldwide. The purpose of the present investigation is to provide some solid evidence for role of the herb <i>Teucrium stocksianum</i> in the treatment of PCOS related ovarian and metabolic derangements.</p> Methods <p>To investigate these possibilities, prepubertal female rats (<i>n</i> = 24) were initially divided in a random manner into two groups: Group I/control (<i>n</i> = 6) received sesame seed oil, and Group II/experimental (<i>n</i> = 18) received testosterone propionate (TP) subcutaneously for 6&#xa0;weeks. On week 7th, Group I continued to serve as control group whereas Group II animals were confirmed for PCOS induction and were equally divided into 3 treatment groups (6 rats each): Group A (TP) continued to receive testosterone propionate, Group B (TP + TSB) received <i>Teucrium stocksianum</i> (500&#xa0;mg/kg body weight), and Group C (TP + MET) received 250&#xa0;mg/kg body weight metformin. Blood samples were collected at the end of the study to examine the levels of fasting plasma glucose (FPG), fasting insulin (FINS), insulin like growth factor-1 (IGF-1), insulin like growth factor binding protein-1 (IGFBP-1), vascular endothelial growth factor (VEGF), testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), estrogen, progesterone and antihyperlipidemic parameters. Ovarian and uterine tissues were used to identify the histopathological changes in all groups.</p> Results <p>Based on the results, prepubertal rats treated with testosterone exhibited endocrine, metabolic, and reproductive abnormalities parallel to those observed clinically in women with PCOS. Our results have shown potential therapeutic effects of <i>Teucrium stocksianum</i>, as significantly improved FPG, FINS, IGFBP-1, VEGF, FSH, LH, TC, HDL and LDL levels were observed whereas nonsignificant changes were observed in terms of IGF-1 and triglyceride levels in the treatment groups. Furthermore, <i>Teucrium stocksianum</i> also reversed the morphological changes in the ovarian and uterine tissues of the rats when compared to the TP rats.</p> Conclusion <p>These findings imply that treatment with <i>Teucrium</i> restored the ovarian imbalances and insulin insensitivity caused by hyperandrogenism and has the ability to minimize the endocrine and metabolic aberrations, suggesting its potential effectiveness in the management of PCOS.</p>

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Ethyl acetate extract of Teucrium stocksianum leaves attenuates hyperandrogenism, suppresses angiogenesis and improves metabolic disturbance in PCOS induced rat model

  • 期刊论文

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  • 发表日期：

    2026年6月14日

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  • Uzma Firdous,
  • Muhammad Nisar,
  • Mehir-un-Nisa Iqbal

摘要

Background

Polycystic ovarian syndrome (PCOS) is a gynaecological disorder associated with complex metabolic and endocrine disruptions in the reproductive aged women worldwide. The purpose of the present investigation is to provide some solid evidence for role of the herb Teucrium stocksianum in the treatment of PCOS related ovarian and metabolic derangements.

Methods

To investigate these possibilities, prepubertal female rats (n = 24) were initially divided in a random manner into two groups: Group I/control (n = 6) received sesame seed oil, and Group II/experimental (n = 18) received testosterone propionate (TP) subcutaneously for 6 weeks. On week 7th, Group I continued to serve as control group whereas Group II animals were confirmed for PCOS induction and were equally divided into 3 treatment groups (6 rats each): Group A (TP) continued to receive testosterone propionate, Group B (TP + TSB) received Teucrium stocksianum (500 mg/kg body weight), and Group C (TP + MET) received 250 mg/kg body weight metformin. Blood samples were collected at the end of the study to examine the levels of fasting plasma glucose (FPG), fasting insulin (FINS), insulin like growth factor-1 (IGF-1), insulin like growth factor binding protein-1 (IGFBP-1), vascular endothelial growth factor (VEGF), testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), estrogen, progesterone and antihyperlipidemic parameters. Ovarian and uterine tissues were used to identify the histopathological changes in all groups.

Results

Based on the results, prepubertal rats treated with testosterone exhibited endocrine, metabolic, and reproductive abnormalities parallel to those observed clinically in women with PCOS. Our results have shown potential therapeutic effects of Teucrium stocksianum, as significantly improved FPG, FINS, IGFBP-1, VEGF, FSH, LH, TC, HDL and LDL levels were observed whereas nonsignificant changes were observed in terms of IGF-1 and triglyceride levels in the treatment groups. Furthermore, Teucrium stocksianum also reversed the morphological changes in the ovarian and uterine tissues of the rats when compared to the TP rats.

Conclusion

These findings imply that treatment with Teucrium restored the ovarian imbalances and insulin insensitivity caused by hyperandrogenism and has the ability to minimize the endocrine and metabolic aberrations, suggesting its potential effectiveness in the management of PCOS.