Scholarlink

Background <p>Fipronil is a new, broad-spectrum phenylpyrazole pesticide used in agriculture veterinary medicine to control insects, fleas and ticks. The excessive use of fipronil, due to its prolonged half-life and bioaccumulation properties, poses potential environmental, human and animal risks. P-coumaric acid is a natural dietary polyphenolic compound with antioxidant and anti-inflammatory properties. The present study aimed to investigate the ameliorative effect of p-coumaric acid on fipronil-induced acute kidney injury. The mice were divided into three groups (vehicle/control, fipronil challenged @ 25&#xa0;mg/kg bodyweight and fipronil challenged @ 25&#xa0;mg/kg bwt + p-coumaric acid-treated @ 100&#xa0;mg/kg bodyweight groups). Hematological, kidney function biomarkers, oxidative stress parameters like lipid peroxidation, superoxide dismutase and catalase, gene expression of NF-κβ2 and histopathology were studied.</p> Results <p>Fipronil administration caused a significant increase in blood urea nitrogen and creatinine. A significant increase in oxidative stress, gene expression of NF-κβ2 as well as downregulation of antioxidant enzymes along with histopathological changes such as degeneration, necrosis of tubular epithelial cells, atrophied renal corpuscles and mononuclear infiltration were observed on fipronil administration. Administration of p-coumaric acid against fipronil caused decreased serum kidney function biomarkers and oxidative stress, decreased gene expression of NF-κβ2, improved the antioxidant enzyme levels and mitigated the structural changes induced by fipronil.</p> Conclusion <p>Thus p-coumaric acid ameliorates the fipronil-induced kidney injury in mice through attenuation of structural changes, oxidative stress, inflammation and restoration of kidney enzyme levels.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Fipronil-induced kidney injury in mice and its attenuation with p-coumaric acid

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月19日

查看全文
  • Sonam Sarita Bal,
  • Geeta Devi Leishangthem,
  • Amarjit Singh

摘要

Background

Fipronil is a new, broad-spectrum phenylpyrazole pesticide used in agriculture veterinary medicine to control insects, fleas and ticks. The excessive use of fipronil, due to its prolonged half-life and bioaccumulation properties, poses potential environmental, human and animal risks. P-coumaric acid is a natural dietary polyphenolic compound with antioxidant and anti-inflammatory properties. The present study aimed to investigate the ameliorative effect of p-coumaric acid on fipronil-induced acute kidney injury. The mice were divided into three groups (vehicle/control, fipronil challenged @ 25 mg/kg bodyweight and fipronil challenged @ 25 mg/kg bwt + p-coumaric acid-treated @ 100 mg/kg bodyweight groups). Hematological, kidney function biomarkers, oxidative stress parameters like lipid peroxidation, superoxide dismutase and catalase, gene expression of NF-κβ2 and histopathology were studied.

Results

Fipronil administration caused a significant increase in blood urea nitrogen and creatinine. A significant increase in oxidative stress, gene expression of NF-κβ2 as well as downregulation of antioxidant enzymes along with histopathological changes such as degeneration, necrosis of tubular epithelial cells, atrophied renal corpuscles and mononuclear infiltration were observed on fipronil administration. Administration of p-coumaric acid against fipronil caused decreased serum kidney function biomarkers and oxidative stress, decreased gene expression of NF-κβ2, improved the antioxidant enzyme levels and mitigated the structural changes induced by fipronil.

Conclusion

Thus p-coumaric acid ameliorates the fipronil-induced kidney injury in mice through attenuation of structural changes, oxidative stress, inflammation and restoration of kidney enzyme levels.