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<p>Fibroblast activation protein (FAP)–targeted PET imaging is an emerging technique that images the tumor stroma by targeting cancer-associated fibroblasts, offering high tumor-to-background contrast and improved lesion detection in tumors with low [¹⁸F]FDG avidity. Given the central role of CAFs in tumor progression and therapy response, FAPI PET has gained interest in neuroendocrine neoplasms (NENs), where stromal imaging may provide complementary information to conventional modalities. This review evaluates the biological rationale, current evidence, and potential clinical role of FAPI PET in the imaging and management of NENs.</p>

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FAPI: a solution to all, what about NENs?

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月9日

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  • Ozgul Ekmekcioglu,
  • Filiz Celik,
  • Simon Hughes,
  • Meltem Ocak,
  • Fred Verzijlbergen,
  • Stefano Fanti,
  • Christophe M. Deroose

摘要

Fibroblast activation protein (FAP)–targeted PET imaging is an emerging technique that images the tumor stroma by targeting cancer-associated fibroblasts, offering high tumor-to-background contrast and improved lesion detection in tumors with low [¹⁸F]FDG avidity. Given the central role of CAFs in tumor progression and therapy response, FAPI PET has gained interest in neuroendocrine neoplasms (NENs), where stromal imaging may provide complementary information to conventional modalities. This review evaluates the biological rationale, current evidence, and potential clinical role of FAPI PET in the imaging and management of NENs.