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Background <p>Sleep disruptions are common among patients undergoing hemodialysis (HD) and peritoneal dialysis (PD), reducing quality of life and clinical outcomes. Emerging evidence suggests that dietary intake may influence sleep quality, yet findings remain inconsistent and no comprehensive synthesis currently exists.</p> Methods <p>A comprehensive systematic search of various databases was conducted for studies published after 2000. The inclusion criteria were observational studies and clinical trials evaluating the relationship between nutrient intake and sleep quality in HD or PD patients.</p> Results <p>Thirteen studies were included (12 cross-sectional and 1 randomized trial). Approximately 62% assessed nutrition using dietary recalls or intake questionnaires, while 38% used biochemical or serum markers. Overall, 10 of 13 studies (77%) reported significant associations, with 6 showing better sleep linked to healthier nutrient profiles (e.g., higher fiber, plant protein, vitamins, selenium) and 4 indicating poorer sleep with higher intake of harmful nutrients such as fat, sodium, and phosphorus (p &lt; 0.05). Three studies (23%) found no association. Most cross-sectional studies were rated at moderate risk of bias, largely due to unclear dietary assessment methods and limited adjustment for confounders, although samples were generally well described and sleep outcomes measured with validated tools.</p> Conclusion <p>There is a complex and significant association between nutrition and sleep quality in dialysis patients. Particular dietary elements and biochemical indicators seem to impact sleep quality, highlighting the need for personalized nutritional evaluation and treatment in addressing sleep issues within this group.</p>

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Investigating the relationship between nutrient intake and sleep quality in dialysis patients: a systematic review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月8日

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  • Reyhane Motamedifard,
  • Shahab Moghadam,
  • Mohammad Hossein Rouhani,
  • Mojgan Mortazavi

摘要

Background

Sleep disruptions are common among patients undergoing hemodialysis (HD) and peritoneal dialysis (PD), reducing quality of life and clinical outcomes. Emerging evidence suggests that dietary intake may influence sleep quality, yet findings remain inconsistent and no comprehensive synthesis currently exists.

Methods

A comprehensive systematic search of various databases was conducted for studies published after 2000. The inclusion criteria were observational studies and clinical trials evaluating the relationship between nutrient intake and sleep quality in HD or PD patients.

Results

Thirteen studies were included (12 cross-sectional and 1 randomized trial). Approximately 62% assessed nutrition using dietary recalls or intake questionnaires, while 38% used biochemical or serum markers. Overall, 10 of 13 studies (77%) reported significant associations, with 6 showing better sleep linked to healthier nutrient profiles (e.g., higher fiber, plant protein, vitamins, selenium) and 4 indicating poorer sleep with higher intake of harmful nutrients such as fat, sodium, and phosphorus (p < 0.05). Three studies (23%) found no association. Most cross-sectional studies were rated at moderate risk of bias, largely due to unclear dietary assessment methods and limited adjustment for confounders, although samples were generally well described and sleep outcomes measured with validated tools.

Conclusion

There is a complex and significant association between nutrition and sleep quality in dialysis patients. Particular dietary elements and biochemical indicators seem to impact sleep quality, highlighting the need for personalized nutritional evaluation and treatment in addressing sleep issues within this group.