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Background <p>Some patients develop post-COVID-19 organizing pneumonia (OP) that is responsive to corticosteroid treatment. This multicenter, case-control study of patients hospitalized for COVID-19 sought to determine the prevalence, risk factors, radiological outcomes, and evolution after treatment.</p> Methods <p>We included 153 consecutive patients with OP and 140 without OP who required hospitalization because of COVID-19 from February to April 2020. OP patients were followed up for 12 months, with visits at 1, 3, 6, and 12 months after hospital discharge.</p> Results <p>Risk factors for OP at hospital admission were advanced age, previous respiratory disease, and elevated C-reactive protein levels. Follow-up computed thoracic (CT) scans performed one year after admission showed progressive improvement in radiological involvement; however, up to 57% of patients with OP remained with fibrotic-like changes. Multivariate analysis showed a significant association of fibrotic pattern with older age, high dose of corticosteroids, and extensive parenchymal lung involvement on admission CT scans.</p> Conclusions <p>Following COVID-19 OP, fibrotic-like changes may persist over the long term. Higher dose of corticosteroids does not seem to be associated with a better prognosis.</p>

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Organizing pneumonia in hospitalized COVID-19 patients: risk factors and long-term outcomes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月5日

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  • Sandra Cuerpo,
  • Fernanda Hernandez-Gonzalez,
  • Mariana Benegas,
  • Nuria Albacar,
  • Alejandra Lopez-Giraldo,
  • Inés Cobo,
  • Samara Suarez,
  • Verónica Torres,
  • Adelaido Salazar,
  • Nestor Soler,
  • María Noboa-Sevilla,
  • Alejandro Frino-García,
  • Nancy Pérez-Rodas,
  • Joel Francesqui,
  • Xavier Alsina-Restoy,
  • Ana María Muñoz Fernández,
  • Nuria Roger,
  • Sergio Prieto,
  • Alexandru Vlagea,
  • Estibaliz Ruiz,
  • Rosa Faner,
  • Joan Albert Barberà,
  • Alex Soriano,
  • Joan Ramon Badia,
  • María Molina-Molina,
  • Oriol Sibila,
  • Marcelo Sánchez,
  • Alvar Agustí,
  • Judith Garcia-Aymerich,
  • Jacobo Sellares

摘要

Background

Some patients develop post-COVID-19 organizing pneumonia (OP) that is responsive to corticosteroid treatment. This multicenter, case-control study of patients hospitalized for COVID-19 sought to determine the prevalence, risk factors, radiological outcomes, and evolution after treatment.

Methods

We included 153 consecutive patients with OP and 140 without OP who required hospitalization because of COVID-19 from February to April 2020. OP patients were followed up for 12 months, with visits at 1, 3, 6, and 12 months after hospital discharge.

Results

Risk factors for OP at hospital admission were advanced age, previous respiratory disease, and elevated C-reactive protein levels. Follow-up computed thoracic (CT) scans performed one year after admission showed progressive improvement in radiological involvement; however, up to 57% of patients with OP remained with fibrotic-like changes. Multivariate analysis showed a significant association of fibrotic pattern with older age, high dose of corticosteroids, and extensive parenchymal lung involvement on admission CT scans.

Conclusions

Following COVID-19 OP, fibrotic-like changes may persist over the long term. Higher dose of corticosteroids does not seem to be associated with a better prognosis.