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Background <p>Xenograft mouse models play an important role in preclinical cancer research, particularly in the development of new therapeutics. To test the efficacy of a combination therapy consisting of radiation and new drug candidates, it is crucial that only the tumor area is irradiated, while other parts of the body are shielded. In this study, a 3D-printed radiopaque back shield was designed for tumor-specific irradiation and evaluated in a xenograft mouse model.</p> Methods <p>Different radiopaque materials were initially tested for their shielding properties using the Multirad 225 X-ray irradiator and the most suitable material was used for printing a back shield with a tumor site-specific opening of the cover. Tumor bearing mice were irradiated four times with a dose of 3.5&#xa0;Gy. To evaluate proper body shielding, blood samples, spleens and bone marrow were examined at the end of the experiment.</p> Results <p>A tungsten filament was identified to be most efficient for shielding and used to 3D print a pie-slice-shaped back shield with a tumor-site specific opening, while polylactic acid was used to print a scaffold that ensured proper positioning of the shield. The simple design allowed cost-efficient and fast 3D printing, easy handling and individual modifications of the tumor site openings. In terms of animal safety, the product provided sufficient shielding in the low-dose irradiation protocols of xenograft mice.</p> Conclusion <p>The custom-designed 3D-printed tungsten back shields provide proper shielding of the animals body and allow for subcutaneous tumor irradiation under standardized conditions.</p>

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Custom-made 3D-printed X-ray shield for tumor-specific irradiation of xenograft mice

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月7日

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  • Markus Lechner,
  • Anna Kolz,
  • Kristina Herre,
  • Dana Matzek,
  • Adrian Schomburg,
  • Bastian Popper

摘要

Background

Xenograft mouse models play an important role in preclinical cancer research, particularly in the development of new therapeutics. To test the efficacy of a combination therapy consisting of radiation and new drug candidates, it is crucial that only the tumor area is irradiated, while other parts of the body are shielded. In this study, a 3D-printed radiopaque back shield was designed for tumor-specific irradiation and evaluated in a xenograft mouse model.

Methods

Different radiopaque materials were initially tested for their shielding properties using the Multirad 225 X-ray irradiator and the most suitable material was used for printing a back shield with a tumor site-specific opening of the cover. Tumor bearing mice were irradiated four times with a dose of 3.5 Gy. To evaluate proper body shielding, blood samples, spleens and bone marrow were examined at the end of the experiment.

Results

A tungsten filament was identified to be most efficient for shielding and used to 3D print a pie-slice-shaped back shield with a tumor-site specific opening, while polylactic acid was used to print a scaffold that ensured proper positioning of the shield. The simple design allowed cost-efficient and fast 3D printing, easy handling and individual modifications of the tumor site openings. In terms of animal safety, the product provided sufficient shielding in the low-dose irradiation protocols of xenograft mice.

Conclusion

The custom-designed 3D-printed tungsten back shields provide proper shielding of the animals body and allow for subcutaneous tumor irradiation under standardized conditions.