Scholarlink

<p>Dengue cases are reported annually in Vung Tau province, southern Vietnam; however, data on viral and host factors associated with disease severity are limited, particularly during epidemics driven by specific serotypes. We investigated the prevalence of dengue virus (DENV), its molecular epidemiology, and clinical–laboratory correlates of severity in patients with suspected dengue at Vung Tau General Hospital between September 2020 and May 2021. Among 1435 suspected cases, 639 (44.5%) were classified as DENV infection-negative, 60 (4.2%) presented with primary infection and 736 (51.3%) with secondary infection. DENV serotyping indicated that DENV-4 was the most prevalent serotype (50 patients, 37.6%), followed by DENV-2 (41, 30.8%), DENV-1 (39, 29.3%), and DENV-3 (3, 2.3%). Phylogenetic analysis revealed DENV-1 genotype I, DENV-2 genotype II (cosmopolitan) and genotype V (Asian I), and DENV-4 genotype I. Notably, DENV-4 exhibited two coexisting clades, suggesting that variations in clade distribution may have contributed to the epidemic. Although parameters commonly associated with dengue severity, such as white blood cell counts, platelet counts, and liver enzyme levels (AST and ALT), were comparable across serotypes, hemoglobin and hematocrit levels were elevated in DENV-4 infections compared with other serotypes. This elevation may indicate a higher risk of plasma leakage, a key feature of severe dengue, underscoring the potential clinical significance of DENV-4 during this epidemic. These findings highlight the epidemiological and clinical importance of DENV-4 and provide evidence for refining dengue control strategies in endemic areas.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Dengue virus serotype 4-leading serotype epidemic and its clinical and molecular characteristics in Vung Tau, South Vietnam, 2020–2021

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月19日

查看全文
  • Ngan Thi Thanh Nguyen,
  • Taichiro Takemura,
  • Motoki Ihara,
  • Kei Yamasato,
  • Tomomi Kurashige,
  • Haruka Abe,
  • Hien Thi Tran,
  • Hieu Vu,
  • Anh Hong Quynh Pham,
  • Hau Thi Bich Vu,
  • Linh Ngoc Nguyen,
  • Hang Thi Thu Pham,
  • Quyen Do Pham,
  • Thu Thi Hien Le,
  • Thuy Thi Thu Nguyen,
  • Phuong Vu Mai Hoang,
  • Hang Le Khanh Nguyen,
  • Tu Tuan Lam,
  • Truong Thien Tran,
  • Lam Thi Le,
  • Kha Hong Vu,
  • Trang Huyen Chu,
  • Mya Myat Ngwe Tun,
  • Kouichi Morita,
  • Yuki Takamatsu,
  • Futoshi Hasebe,
  • Mai Thi Quynh Le

摘要

Dengue cases are reported annually in Vung Tau province, southern Vietnam; however, data on viral and host factors associated with disease severity are limited, particularly during epidemics driven by specific serotypes. We investigated the prevalence of dengue virus (DENV), its molecular epidemiology, and clinical–laboratory correlates of severity in patients with suspected dengue at Vung Tau General Hospital between September 2020 and May 2021. Among 1435 suspected cases, 639 (44.5%) were classified as DENV infection-negative, 60 (4.2%) presented with primary infection and 736 (51.3%) with secondary infection. DENV serotyping indicated that DENV-4 was the most prevalent serotype (50 patients, 37.6%), followed by DENV-2 (41, 30.8%), DENV-1 (39, 29.3%), and DENV-3 (3, 2.3%). Phylogenetic analysis revealed DENV-1 genotype I, DENV-2 genotype II (cosmopolitan) and genotype V (Asian I), and DENV-4 genotype I. Notably, DENV-4 exhibited two coexisting clades, suggesting that variations in clade distribution may have contributed to the epidemic. Although parameters commonly associated with dengue severity, such as white blood cell counts, platelet counts, and liver enzyme levels (AST and ALT), were comparable across serotypes, hemoglobin and hematocrit levels were elevated in DENV-4 infections compared with other serotypes. This elevation may indicate a higher risk of plasma leakage, a key feature of severe dengue, underscoring the potential clinical significance of DENV-4 during this epidemic. These findings highlight the epidemiological and clinical importance of DENV-4 and provide evidence for refining dengue control strategies in endemic areas.