Scholarlink

Background <p>This study explored the role of myocardial injury in the prognostic assessment of severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS) patients, and analyzed its risk factors.</p> Methods <p>A retrospective study included 188 SFTS and 101 HFRS patients (2020–2024) from two hospitals. Epidemiological, clinical, and laboratory data were dynamically recorded and statistically analyzed.</p> Results <p>SFTS patients were older (65.35 ± 11.04 vs. 53.26 ± 14.66&#xa0;years) and had more females (56.90% vs. 26.70%, both P &lt; 0.001). HFRS was more likely to present early symptoms (myalgia, fatigue/anorexia, abdominal pain, diarrhea, vomiting, skin petechiae/ecchymosis, headache; all P ≤ 0.040). SFTS mortality (19.70%, 37/188) was significantly higher than HFRS (4.00%, 4/101, P &lt; 0.001). Both groups had elevated myocardial markers (ALT, AST, CK, CK-MB, cTn, LDH, α-HBDH): HFRS had higher levels during days 3–7 (which then decreased), while SFTS levels increased and exceeded those of HFRS during days 8–14. SFTS patients with myocardial injury had higher mortality (29.10% vs. 11.80%, P = 0.003), but HFRS showed no mortality difference between those with and without myocardial injury (P = 0.952). Myocardial injury risk factors emerged in both groups during days 3–7, increased during days 8–14, peaking on day 10 (SFTS) and days 6/12/13 (HFRS).</p> Conclusion <p>SFTS has a higher mortality rate. Myocardial injury is common and early in both groups: HFRS patients show rapid recovery, while SFTS patients experience worsening injury associated with death. Early intervention targeting risk factors is key to reducing mortality.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Divergent prognostic roles and risk determinants of myocardial injury in SFTS and HFRS

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月17日

查看全文
  • Yihui Sun,
  • Xiaoyi Wang,
  • Jing Sun,
  • Yao Hao,
  • Yingchun Sun,
  • Zhiyu Pan,
  • Zijian Wang,
  • Aiping Zhang,
  • Manman Liang,
  • Jianghua Yang

摘要

Background

This study explored the role of myocardial injury in the prognostic assessment of severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS) patients, and analyzed its risk factors.

Methods

A retrospective study included 188 SFTS and 101 HFRS patients (2020–2024) from two hospitals. Epidemiological, clinical, and laboratory data were dynamically recorded and statistically analyzed.

Results

SFTS patients were older (65.35 ± 11.04 vs. 53.26 ± 14.66 years) and had more females (56.90% vs. 26.70%, both P < 0.001). HFRS was more likely to present early symptoms (myalgia, fatigue/anorexia, abdominal pain, diarrhea, vomiting, skin petechiae/ecchymosis, headache; all P ≤ 0.040). SFTS mortality (19.70%, 37/188) was significantly higher than HFRS (4.00%, 4/101, P < 0.001). Both groups had elevated myocardial markers (ALT, AST, CK, CK-MB, cTn, LDH, α-HBDH): HFRS had higher levels during days 3–7 (which then decreased), while SFTS levels increased and exceeded those of HFRS during days 8–14. SFTS patients with myocardial injury had higher mortality (29.10% vs. 11.80%, P = 0.003), but HFRS showed no mortality difference between those with and without myocardial injury (P = 0.952). Myocardial injury risk factors emerged in both groups during days 3–7, increased during days 8–14, peaking on day 10 (SFTS) and days 6/12/13 (HFRS).

Conclusion

SFTS has a higher mortality rate. Myocardial injury is common and early in both groups: HFRS patients show rapid recovery, while SFTS patients experience worsening injury associated with death. Early intervention targeting risk factors is key to reducing mortality.