Cyclotron production of manganese-52: a promising avenue for multimodal PET/MRI imaging

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2024年8月2日

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Francesca Porto,
Sara Cisternino,
Emiliano Cazzola,
Giorgia Speltri,
Liliana Mou,
Alessandra Boschi,
Lorenza Marvelli,
Giovanni Di Domenico,
Antonella Pagnoni,
Lucia De Dominicis,
Irene Calliari,
Claudio Gennari,
Licia Uccelli,
Gaia Pupillo,
Giancarlo Gorgoni,
Juan Esposito,
Petra Martini

摘要

Background

The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) holds promise for advancing diagnostic imaging capabilities. The METRICS project aims to develop cyclotron-driven production of ⁵²Mn for PET/MRI imaging.

Results

Using the ⁵²Cr(p,n)⁵²Mn reaction, we designed chromium metal targets via Spark Plasma Sintering and developed a separation procedure for isolating ⁵²Mn. Labeling tests were conducted with traditional chelators (i.e. S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid) and the 1.4-dioxa-8-azaspiro[4.5]decane-8- carbodithioate ligand to produce radioactive complexes suitable for PET/MRI applications. Our methodology yielded high-quality ⁵²Mn suitable for PET radiopharmaceuticals and PET/MRI imaging. Preliminary studies on phantom imaging using microPET and clinical MRI demonstrated the efficacy of our approach.

Conclusions

The developed technology offers a promising avenue for producing ⁵²Mn and enhancing PET/MRI imaging capabilities. Further in vivo investigations are warranted to evaluate the potential advantages of this hybrid imaging technique.