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Background <p>This double-blind, randomized clinical trial (RCT) assessed whether supplementation with extra virgin rice bran oil (RBO) capsules provides additional metabolic benefits in type-2 diabetes mellitus (T2DM) patients following a standard diet with olive oil as their primary fat source.</p> Methods <p>Fifty adults with T2DM were randomly assigned to receive either 1&#xa0;g/day RBO capsules (24.1&#xa0;mg γ-oryzanol) or placebo (1&#xa0;g/day MCT oil) for 12 weeks, alongside a standard olive oil-based diet. Primary outcomes included changes in glycemic control and insulin resistance (IR); secondary outcomes assessed antioxidant status, lipid profiles, atherogenicity, and IR surrogate markers. (IRCT20180205038626N12).</p> Results <p>Of 50 randomized participants, 46 completed the trial. Compared to placebo, RBO significantly reduced fasting glucose (effect size [ES]: -0.67; P-value = 0.003) and marginally improved HOMA-IR (ES: -0.57; P-value = 0.063). Antioxidant capacity (ES: 1.60; P-value &lt; 0.001) and superoxide dismutase (ES: 1.15; P-value = 0.007) increased significantly. RBO also lowered total cholesterol (ES: -1.12; P-value &lt; 0.001), LDL-C (ES: -0.63; P-value = 0.042), and improved atherogenic index (ES: -0.81; P-value = 0.009), METS-IR (ES: -0.67; P-value = 0.029), TyG index (ES: -1.80; P-value = 0.019), and TyG-BMI (ES: -0.76; P-value = 0.013). No significant between-group changes occurred in HbA1c, postprandial glucose, triglycerides, or BMI.</p> Conclusion <p>Twelve weeks of extra virgin RBO supplementation improved fasting glucose, IR markers, antioxidant defense, lipid profiles, and atherogenicity in T2DM patients, though HbA1c and postprandial glucose did not differ significantly between groups. Larger, longer-term studies are needed to confirm these benefits.</p>

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Does Extra Virgin Rice Bran Oil Supplementation Provide Additional Benefits for Type 2 Diabetes Patients on a Standard Diet with Olive Oil? A Randomized Clinical Trial

  • 期刊论文

  • 发表日期：

    2026年7月10日

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  • Zeinab Ghorbani,
  • Ali Bonyad,
  • Sara Khoshdooz,
  • Marjan Mahdavi-Roshan,
  • Behrang Motamed,
  • Ehsan Zamani,
  • Amir Pourfarzad

摘要

Background

This double-blind, randomized clinical trial (RCT) assessed whether supplementation with extra virgin rice bran oil (RBO) capsules provides additional metabolic benefits in type-2 diabetes mellitus (T2DM) patients following a standard diet with olive oil as their primary fat source.

Methods

Fifty adults with T2DM were randomly assigned to receive either 1 g/day RBO capsules (24.1 mg γ-oryzanol) or placebo (1 g/day MCT oil) for 12 weeks, alongside a standard olive oil-based diet. Primary outcomes included changes in glycemic control and insulin resistance (IR); secondary outcomes assessed antioxidant status, lipid profiles, atherogenicity, and IR surrogate markers. (IRCT20180205038626N12).

Results

Of 50 randomized participants, 46 completed the trial. Compared to placebo, RBO significantly reduced fasting glucose (effect size [ES]: -0.67; P-value = 0.003) and marginally improved HOMA-IR (ES: -0.57; P-value = 0.063). Antioxidant capacity (ES: 1.60; P-value < 0.001) and superoxide dismutase (ES: 1.15; P-value = 0.007) increased significantly. RBO also lowered total cholesterol (ES: -1.12; P-value < 0.001), LDL-C (ES: -0.63; P-value = 0.042), and improved atherogenic index (ES: -0.81; P-value = 0.009), METS-IR (ES: -0.67; P-value = 0.029), TyG index (ES: -1.80; P-value = 0.019), and TyG-BMI (ES: -0.76; P-value = 0.013). No significant between-group changes occurred in HbA1c, postprandial glucose, triglycerides, or BMI.

Conclusion

Twelve weeks of extra virgin RBO supplementation improved fasting glucose, IR markers, antioxidant defense, lipid profiles, and atherogenicity in T2DM patients, though HbA1c and postprandial glucose did not differ significantly between groups. Larger, longer-term studies are needed to confirm these benefits.