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Purpose <p>The expanding understanding of the gut microbiota’s complexity has underscored its pivotal role in human health, particularly in the prevention and management of cardiovascular diseases. This study aims to compile and synthesize current evidence from the literature to consolidate existing knowledge and identify research gaps, thereby informing and guiding future investigations into the use of probiotics, prebiotics, and synbiotics.</p> Methods <p>A scoping review was conducted using PubMed, LILACS, and the Cochrane Library. The inclusion criteria encompassed studies directly addressing the central topic and containing the following descriptors combined with Boolean operators: (gut OR microbiome OR microbiota OR dysbiosis) AND (hypertension OR high blood pressure) AND (prebiotics OR probiotics OR synbiotics).</p> Results <p>A total of 728 articles were initially identified. After the removal of 24 duplicates, 704 articles remained for title and abstract screening. Based on predefined eligibility criteria, 672 articles were excluded after full-text review. The analysis revealed that interventions with probiotics, prebiotics, and synbiotics demonstrated potential benefits in modulating blood pressure and endothelial function, although findings remain inconsistent and limited by methodological heterogeneity.</p> Conclusion <p>Further research is required to enhance the understanding of the intricate interactions between the gut microbiota, host characteristics, and therapeutic outcomes. Although this emerging approach shows promise in the treatment of endothelial dysfunction and hypertension, its effectiveness must be confirmed through more rigorous and large-scale clinical trials.</p>

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Adjunctive use of probiotics, prebiotics, and synbiotics in endothelial dysfunction and hypertension management: a scoping review

  • 期刊论文

  • 发表日期：

    2026年5月4日

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  • Sophia Veríssimo Tofoli,
  • Laura Oreste de Andrade,
  • Alexandre Cauã Bernardes Ribeiro,
  • Pedro Lucas Schimack Cosentino,
  • Felipe Malta de Paula,
  • Mariana Vanzolini Segato,
  • Aline Barbosa Ribeiro

摘要

Purpose

The expanding understanding of the gut microbiota’s complexity has underscored its pivotal role in human health, particularly in the prevention and management of cardiovascular diseases. This study aims to compile and synthesize current evidence from the literature to consolidate existing knowledge and identify research gaps, thereby informing and guiding future investigations into the use of probiotics, prebiotics, and synbiotics.

Methods

A scoping review was conducted using PubMed, LILACS, and the Cochrane Library. The inclusion criteria encompassed studies directly addressing the central topic and containing the following descriptors combined with Boolean operators: (gut OR microbiome OR microbiota OR dysbiosis) AND (hypertension OR high blood pressure) AND (prebiotics OR probiotics OR synbiotics).

Results

A total of 728 articles were initially identified. After the removal of 24 duplicates, 704 articles remained for title and abstract screening. Based on predefined eligibility criteria, 672 articles were excluded after full-text review. The analysis revealed that interventions with probiotics, prebiotics, and synbiotics demonstrated potential benefits in modulating blood pressure and endothelial function, although findings remain inconsistent and limited by methodological heterogeneity.

Conclusion

Further research is required to enhance the understanding of the intricate interactions between the gut microbiota, host characteristics, and therapeutic outcomes. Although this emerging approach shows promise in the treatment of endothelial dysfunction and hypertension, its effectiveness must be confirmed through more rigorous and large-scale clinical trials.