<p>Chronic kidney disease (CKD) is a prevalent and complex disorder in the current clinical landscape. Adequate intake of essential micronutrients is required to reduce inflammation, oxidative stress, and metabolic disturbances associated with renal dysfunction. This review highlights the role of metabolomics in characterising metabolic alterations in CKD, including disruptions in amino acid metabolism, oxidative stress pathways, and the accumulation of uremic toxins. These metabolomic insights provide a molecular basis for developing personalised, micronutrient-based dietary interventions. Micronutrients such as iron, calcium, magnesium, zinc, selenium, and vitamins B6, B12, C, and folic acid play critical roles in cellular repair, immune function, antioxidant defence, and bone integrity. Fluid intake regulation is equally important, as overload can exacerbate hypertension and edema in individuals with impaired kidney function. As CKD progresses, careful dietary and fluid management becomes increasingly essential for maintaining blood pressure, electrolyte balance, and overall metabolic stability. A well-structured and therapeutic dietary strategy is therefore fundamental not only for preserving residual kidney function but also for improving systemic metabolic health. This review underscores the importance of nutritional strategies for CKD patients and demonstrates how optimising micronutrient intake, guided by metabolomic and clinical evidence, can enhance patient outcomes and improve quality of life for those with kidney disease. </p>