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<p>The testes have two critical roles: spermatogenesis and the production of steroids, such as testosterone, which are regulated by the hypothalamic-pituitary-gonadal axis, as well as peptides including asprosin. Asprosin is a fasting-induced adipokine involved in hepatic glucose regulation. In order to elaborate on the interrelations between asprosin and testis metabolism, we aimed to investigate the effects of progressive pyramidal shuttle run training along with/and <i>Cyperus rotundus</i> root extract supplementation, on serum and testicular levels of asprosin, testosterone, and testis glycogen concentrations in male wistar rats. Thirty two male Wistar rats (4–6 week-old, 120–150 g) were randomly divided into four groups: (1)&#xa0;Saline Control (SC: <i>n</i> = 8); (2)&#xa0;Saline Training (ST: <i>n</i> = 8); (3)&#xa0;<i>Cyperus rotundus</i> supplement (CRS: <i>n</i> = 8); (4)&#xa0;<i>Cyperus rotundus</i> + Training (CRT: <i>n</i> = 8). The training groups underwent 8 weeks of progressive pyramidal treadmill running (10–60 m/min for 61–62 min). The supplement groups received <i>Cyperus rotundus</i> root extract (2 g/kg in 20 mL of saline solution) orally. About 72 h subsequent to the end of the intervention, Serum and testis tissue samples were collected to measure asprosin, testosterone, and glycogen levels. Data were analyzed using one-way ANOVA, followed by the Bonferroni <i>post-hoc</i> test and reported at the significance level of <i>P</i> &lt; 0.05. No significant changes were observed in serum asprosin and testosterone levels, or testicular glycogen and testosterone concentration (<i>P</i> &lt; 0.05). However, testicular asprosin levels significantly increased in the CRS and CRT groups. In conclusion, both training and <i>Cyperus rotundus</i> supplementation increased testicular asprosin, suggesting that this hormone may act locally within testicular tissue, probably independent of Glycogen levels. Due to its antioxidant, carbohydrate, and mineral contents, <i>Cyperus rotundus</i> may exert protective effects against training-induced testicular disruptions in spermatogenesis and testosterone production.</p> Graphical abstract <p></p>

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Cyperus rotundus root extract and pyramidal training enhance testicular Asprosin dynamics in male Wistar Rats, independant of glycogen levels

  • 期刊论文

  • 发表日期：

    2025年11月25日

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  • Seyed Ali khazaei,
  • Abbass Ghanbari-Niaki,
  • Nader Hamedchaman,
  • Gholamreza Hamidian

摘要

The testes have two critical roles: spermatogenesis and the production of steroids, such as testosterone, which are regulated by the hypothalamic-pituitary-gonadal axis, as well as peptides including asprosin. Asprosin is a fasting-induced adipokine involved in hepatic glucose regulation. In order to elaborate on the interrelations between asprosin and testis metabolism, we aimed to investigate the effects of progressive pyramidal shuttle run training along with/and Cyperus rotundus root extract supplementation, on serum and testicular levels of asprosin, testosterone, and testis glycogen concentrations in male wistar rats. Thirty two male Wistar rats (4–6 week-old, 120–150 g) were randomly divided into four groups: (1) Saline Control (SC: n = 8); (2) Saline Training (ST: n = 8); (3) Cyperus rotundus supplement (CRS: n = 8); (4) Cyperus rotundus + Training (CRT: n = 8). The training groups underwent 8 weeks of progressive pyramidal treadmill running (10–60 m/min for 61–62 min). The supplement groups received Cyperus rotundus root extract (2 g/kg in 20 mL of saline solution) orally. About 72 h subsequent to the end of the intervention, Serum and testis tissue samples were collected to measure asprosin, testosterone, and glycogen levels. Data were analyzed using one-way ANOVA, followed by the Bonferroni post-hoc test and reported at the significance level of P < 0.05. No significant changes were observed in serum asprosin and testosterone levels, or testicular glycogen and testosterone concentration (P < 0.05). However, testicular asprosin levels significantly increased in the CRS and CRT groups. In conclusion, both training and Cyperus rotundus supplementation increased testicular asprosin, suggesting that this hormone may act locally within testicular tissue, probably independent of Glycogen levels. Due to its antioxidant, carbohydrate, and mineral contents, Cyperus rotundus may exert protective effects against training-induced testicular disruptions in spermatogenesis and testosterone production.

Graphical abstract