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<p>Doxorubicin-induced cardiotoxicity is primarily driven by oxidative stress, inflammation, apoptosis, and autophagic dysregulation, leading to cardiac dysfunction and structural damage. This study evaluated the cardioprotective effects of lutein, a natural carotenoid with antioxidant and anti-inflammatory properties, in male Wistar rats. Rats were pretreated with lutein (40&#xa0;mg/kg, intraperitoneally) for 25 days before receiving doxorubicin (15&#xa0;mg/kg for 3 days). Doxorubicin exposure caused marked cardiotoxicity, evidenced by increased oxidative stress, inflammation, apoptosis, dysregulated Beclin-1/mTOR signaling, myofibrillar disintegration, histological alterations, and elevated serum troponin-I and CK-MB levels. Pretreatment with lutein significantly attenuated these changes, reducing oxidative stress, inflammatory responses, apoptosis, and autophagic dysregulation, while also lowering troponin-I and CK-MB leakage. Histological integrity of cardiac tissue was better preserved in lutein-pretreated rats. Overall, lutein exhibited potent cardioprotective effects against doxorubicin-induced cardiac injury by mitigating oxidative stress-mediated alterations in Beclin-1/mTOR activity and associated pathological sequelae.</p>

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Lutein protects against oxidative stress-mediated dysregulation of cardiac Beclin-1/mTOR activities and other pathological sequalae in rats exposed to doxorubicin

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • Jerome Ndudi Asiwe,
  • Godwin D. Yovwin,
  • Stephanie Alero Omatseye,
  • Mary Kokori,
  • Ebruvweyoghene Akpotor,
  • Precious Oghenerukevwe Fabulous,
  • Eugenia Oghenefego Adueniwoma,
  • Success Okuchukwu Joseph,
  • Bridget Ovenomo Ogodo,
  • Faith Omua Ogbebor,
  • Marialucia Amaka Osian

摘要

Doxorubicin-induced cardiotoxicity is primarily driven by oxidative stress, inflammation, apoptosis, and autophagic dysregulation, leading to cardiac dysfunction and structural damage. This study evaluated the cardioprotective effects of lutein, a natural carotenoid with antioxidant and anti-inflammatory properties, in male Wistar rats. Rats were pretreated with lutein (40 mg/kg, intraperitoneally) for 25 days before receiving doxorubicin (15 mg/kg for 3 days). Doxorubicin exposure caused marked cardiotoxicity, evidenced by increased oxidative stress, inflammation, apoptosis, dysregulated Beclin-1/mTOR signaling, myofibrillar disintegration, histological alterations, and elevated serum troponin-I and CK-MB levels. Pretreatment with lutein significantly attenuated these changes, reducing oxidative stress, inflammatory responses, apoptosis, and autophagic dysregulation, while also lowering troponin-I and CK-MB leakage. Histological integrity of cardiac tissue was better preserved in lutein-pretreated rats. Overall, lutein exhibited potent cardioprotective effects against doxorubicin-induced cardiac injury by mitigating oxidative stress-mediated alterations in Beclin-1/mTOR activity and associated pathological sequelae.