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Background <p>Oxidative injury to lens epithelial cells (LECs) is directly associated with cataracts, a major contributor to blindness globally.</p> Objective <p>This work aimed to examine the mitigative impacts of <i>Curcuma longa</i> extract on selenite-evoked cataract in rabbits.</p> Methods <p>Twelve rabbits were divided into three groups: healthy controls, a sodium selenite-induced cataract group, and a treatment group receiving both sodium selenite and <i>Curcuma longa</i> extract eye drops. A single intravitreal injection of sodium selenite led to the inducement of a cataract in the right eye of rabbits. The main indicators were ophthalmoscope readings, scanning electron microscope images of the eye’s lenses, and intraocular pressure (IOP) measurements together with the amount of malondialdehyde (MDA) in the aqueous humor.</p> Results <p>The mean of the lens opacity score and MDA level was significantly reduced by <i>Curcuma longa</i> extract eye drops as juxtaposed to the cataract-aggravated group (<i>p</i> &lt; 0.01). The homogeneous structure of the lens is demonstrated in the scanning electron microscope image of the lens that was treated with <i>Curcuma longa</i> extract eye drops.</p> Conclusion <p>The eye drops prepared from the acetone extract of <i>Curcuma longa</i> demonstrated remarkable preventive actions on sodium selenite-induced cataracts in the rabbit model.</p> Graphical Abstract <p></p>

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Anti-cataractogenic impact of Curcuma longa extract eye drops on rabbit model of sodium selenite-induced oxidative injury

  • 期刊论文

  • 发表日期：

    2025年9月5日

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  • Omar Adil Hassan,
  • Ahmed Rahmah Abu-raghif,
  • Hayder Ridha-Salman,
  • Alaa Hamza Abbas

摘要

Background

Oxidative injury to lens epithelial cells (LECs) is directly associated with cataracts, a major contributor to blindness globally.

Objective

This work aimed to examine the mitigative impacts of Curcuma longa extract on selenite-evoked cataract in rabbits.

Methods

Twelve rabbits were divided into three groups: healthy controls, a sodium selenite-induced cataract group, and a treatment group receiving both sodium selenite and Curcuma longa extract eye drops. A single intravitreal injection of sodium selenite led to the inducement of a cataract in the right eye of rabbits. The main indicators were ophthalmoscope readings, scanning electron microscope images of the eye’s lenses, and intraocular pressure (IOP) measurements together with the amount of malondialdehyde (MDA) in the aqueous humor.

Results

The mean of the lens opacity score and MDA level was significantly reduced by Curcuma longa extract eye drops as juxtaposed to the cataract-aggravated group (p < 0.01). The homogeneous structure of the lens is demonstrated in the scanning electron microscope image of the lens that was treated with Curcuma longa extract eye drops.

Conclusion

The eye drops prepared from the acetone extract of Curcuma longa demonstrated remarkable preventive actions on sodium selenite-induced cataracts in the rabbit model.

Graphical Abstract