Scholarlink

Purpose <p>The coexistence of excess adiposity, reduced muscle strength, and decreased muscle mass may be associated with vitamin D deficiency. This association has not been previously studied in hemodialysis (HD) patients.</p> Aim <p>This study aimed to identify whether sarcopenia and obesity, separately and combined, are associated with vitamin D deficiency in HD patients<b>.</b></p> Methods <p>This cross-sectional study enrolled 237 individuals aged 18&#xa0;years or older, of both sexes, on maintenance HD. Vitamin D deficiency was defined as a 25(OH)D level &lt; 20&#xa0;ng/dL. Sarcopenia was defined as the presence of both diminished muscle strength and low muscle mass. Obesity was classified by body mass index (BMI) &gt; 30&#xa0;kg/m<sup>2</sup>. The participants were classified as non- sarcopenic non-obese, sarcopenic, obese without sarcopenia and sarcopenic obesity.</p> Results <p>A total of 237 patients were analyzed, mean age was 59 (48–68) years, and 56.9% were men. The prevalence of patients non- sarcopenic non-obese, sarcopenic, obese without sarcopenia, and sarcopenic obesity was 53.6% (<i>n</i> = 127), 23.6% (<i>n</i> = 56), 11.4% (<i>n</i> = 27), and 11.4% (<i>n</i> = 27), respectively. Vitamin D concentrations were 28.9 (19.5–39.6) ng/mL, and 26.6% (<i>n</i> = 63) of the patients were considered deficient. In the adjusted logistic regression model, sarcopenia (OR = 4.02, 95% CI: 1.700–9.486, <i>p</i> = 0.002), obesity (OR = 2.85, 95% CI: 1.008–8.040, <i>p</i> = 0;048) and sarcopenic obesity (OR = 3.05, 95% CI: 1.119–8.326, <i>p</i> = 0.029) were significantly associated with increased odds of vitamin D deficiency.</p> Conclusions <p>Sarcopenia, obesity, and sarcopenic obesity were associated with an increased risk of vitamin D deficiency. Notably, patients with sarcopenia alone showed the strongest association, suggesting that muscle loss may play a major role in relation to excess weight on vitamin D status.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phenotypes of body composition and their associations with vitamin D deficiency in hemodialysis patients

  • 期刊论文

  • 发表日期：

    2025年8月6日

查看全文
  • Clara Sandra de Araújo Sugizaki,
  • Jéssica Ferreira Mayrink Ivo,
  • Karina de Jesus Antônio,
  • Jacqueline Costa Teixeira Caramori,
  • Fernanda Gonçalves Guidetti Homelis,
  • Milene Peron Rodrigues Losilla,
  • Natália Baraldi Cunha,
  • Maria do Rosário Gondim Peixoto,
  • Barbara Perez Vogt,
  • Nara Aline Costa

摘要

Purpose

The coexistence of excess adiposity, reduced muscle strength, and decreased muscle mass may be associated with vitamin D deficiency. This association has not been previously studied in hemodialysis (HD) patients.

Aim

This study aimed to identify whether sarcopenia and obesity, separately and combined, are associated with vitamin D deficiency in HD patients.

Methods

This cross-sectional study enrolled 237 individuals aged 18 years or older, of both sexes, on maintenance HD. Vitamin D deficiency was defined as a 25(OH)D level < 20 ng/dL. Sarcopenia was defined as the presence of both diminished muscle strength and low muscle mass. Obesity was classified by body mass index (BMI) > 30 kg/m2. The participants were classified as non- sarcopenic non-obese, sarcopenic, obese without sarcopenia and sarcopenic obesity.

Results

A total of 237 patients were analyzed, mean age was 59 (48–68) years, and 56.9% were men. The prevalence of patients non- sarcopenic non-obese, sarcopenic, obese without sarcopenia, and sarcopenic obesity was 53.6% (n = 127), 23.6% (n = 56), 11.4% (n = 27), and 11.4% (n = 27), respectively. Vitamin D concentrations were 28.9 (19.5–39.6) ng/mL, and 26.6% (n = 63) of the patients were considered deficient. In the adjusted logistic regression model, sarcopenia (OR = 4.02, 95% CI: 1.700–9.486, p = 0.002), obesity (OR = 2.85, 95% CI: 1.008–8.040, p = 0;048) and sarcopenic obesity (OR = 3.05, 95% CI: 1.119–8.326, p = 0.029) were significantly associated with increased odds of vitamin D deficiency.

Conclusions

Sarcopenia, obesity, and sarcopenic obesity were associated with an increased risk of vitamin D deficiency. Notably, patients with sarcopenia alone showed the strongest association, suggesting that muscle loss may play a major role in relation to excess weight on vitamin D status.