Scholarlink

Purpose <p>Global cerebral ischemia (GCI) reduces cerebral blood flow, leading to neuronal injury, particularly in the hippocampus’s region. Cinnamaldehyde (CI) and curcumin (CUR), known for their antioxidant and anti-inflammatory properties,&#xa0;in this study they were evaluated for their individual and combined effects in mitigating GCI.</p> Methods <p>Fifty male Wistar rats were divided into five groups: Sham, GCI, GCI + CUR, GCI + CI, and GCI + CUR + CI. GCI was induced by occluding the common carotid arteries for 20&#xa0;min. Rats received 100&#xa0;mg/kg CUR, CI, and their combination 15&#xa0;min after GCI. Behavioral memory was assessed using the Y-maze, and hippocampal tissues were utilized for stereological analysis and antioxidant response.</p> Results <p>The GCI + CUR + CI group showed the best improvement in memory and reduced neuronal damage compared to the GCI group and the combination exhibited subadditive effects. CI alone proved more effective in enhancing improvement than CUR.</p> Conclusion <p>CUR and CI reduce GCI-induced damage and improve antioxidant defences, with CI showing superior efficacy. The combined treatment provides subadditive benefits. Further research is needed to understand their combined effects and fully refine neuroprotective strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evaluating the neuroprotective effects of curcumin and cinnamaldehyde, individually and in combination, in a rat model of global cerebral ischemia

  • 期刊论文

  • 发表日期：

    2025年6月19日

查看全文
  • Mohammad Amin Dehghani,
  • Abbas Shahedi,
  • Mohammadreza Namavar,
  • Dariush Mehboodi,
  • Amirhossein Rafiee

摘要

Purpose

Global cerebral ischemia (GCI) reduces cerebral blood flow, leading to neuronal injury, particularly in the hippocampus’s region. Cinnamaldehyde (CI) and curcumin (CUR), known for their antioxidant and anti-inflammatory properties, in this study they were evaluated for their individual and combined effects in mitigating GCI.

Methods

Fifty male Wistar rats were divided into five groups: Sham, GCI, GCI + CUR, GCI + CI, and GCI + CUR + CI. GCI was induced by occluding the common carotid arteries for 20 min. Rats received 100 mg/kg CUR, CI, and their combination 15 min after GCI. Behavioral memory was assessed using the Y-maze, and hippocampal tissues were utilized for stereological analysis and antioxidant response.

Results

The GCI + CUR + CI group showed the best improvement in memory and reduced neuronal damage compared to the GCI group and the combination exhibited subadditive effects. CI alone proved more effective in enhancing improvement than CUR.

Conclusion

CUR and CI reduce GCI-induced damage and improve antioxidant defences, with CI showing superior efficacy. The combined treatment provides subadditive benefits. Further research is needed to understand their combined effects and fully refine neuroprotective strategies.