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Purpose <p>Jambolan is a fruit rich in phenolic compounds and anthocyanins, bioactive compounds that have a positive effect on cardiovascular diseases. The purpose of this study was to evaluate the effects of jambolan on cardiovascular biomarkers and hepatic damage in mice fed a high-fat diet.</p> Methods <p>44 mice received a normolipidic diet or high-fat diet for 8&#xa0;weeks. Afterwards, the animals were divided into four experimental groups (n = 11): normolipidic diet (ND), normolipidic diet with 2% jambolan (ND + J), high-fat diet (HF), high-fat diet with 2% jambolan (HF + J) for 9&#xa0;weeks.</p> Results <p>Jambolan decreased e-selectin and ICAM- 1 concentrations (<i>p</i> &lt; 0.05) when fed with a high-fat diet. Jambolan reduced AST concentration regardless of the diet (<i>p</i> &lt; 0.05) and steatosis degree in the liver.</p> Conclusion <p>Jambolan shows cardiac and hepatoprotective effects, against metabolic changes induced by a high-fat diet.</p>

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Jambolan (Syzygium cumini) mitigates vascular inflammation and liver damage in mice fed a high-fat diet

  • 期刊论文

  • 发表日期：

    2025年4月9日

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  • Roberta de Oliveira Bernardes,
  • Laíz Aparecida Azevedo Silva,
  • Cíntia Tomaz Sant’ Ana,
  • Juliana Almeida Moreira,
  • Maria das Graças Vaz Tostes,
  • Pollyanna Ibrahim Silva,
  • Neuza Maria Brunoro Costa,
  • Erika Takagi Nunes,
  • André Gustavo Vasconcelos Costa

摘要

Purpose

Jambolan is a fruit rich in phenolic compounds and anthocyanins, bioactive compounds that have a positive effect on cardiovascular diseases. The purpose of this study was to evaluate the effects of jambolan on cardiovascular biomarkers and hepatic damage in mice fed a high-fat diet.

Methods

44 mice received a normolipidic diet or high-fat diet for 8 weeks. Afterwards, the animals were divided into four experimental groups (n = 11): normolipidic diet (ND), normolipidic diet with 2% jambolan (ND + J), high-fat diet (HF), high-fat diet with 2% jambolan (HF + J) for 9 weeks.

Results

Jambolan decreased e-selectin and ICAM- 1 concentrations (p < 0.05) when fed with a high-fat diet. Jambolan reduced AST concentration regardless of the diet (p < 0.05) and steatosis degree in the liver.

Conclusion

Jambolan shows cardiac and hepatoprotective effects, against metabolic changes induced by a high-fat diet.