Background <p>Food addiction (FA) is a novel concept defined by a severe desire to consume hyper-palatable meals, which appears to be more prevalent among undergraduates.</p> Aim <p>This study aimed to assess the prevalence of food addiction among medical and non-medical students, as well as the factors that predicted food addiction symptoms among university students in Egypt.</p> Methodology <p>A cross-sectional study included 940 students, with 470 students from the Faculty of Medicine and 470 from the Faculty of Commerce who completed a questionnaire that included the Yale Food Addiction Scale (YFAS 2.0) to examine its association with body composition, quality of sleep, anxiety problems, physical activity/sedentary behaviors, and tobacco use.</p> Results <p>Up to 14.5% of medical students and 10.2% of non-medical undergraduates reported food addiction, and this difference was statistically significant (<i>p</i> = 0.03*). The percent change between both groups was 29% as medical students were more likely to develop food addiction than non-medical students. The predictor variable sex, being male, showed a significant positive coefficient (<i>p</i> = 0.0001*). Concerning body mass index (BMI), being underweight and normal weight are negative predictors for the development of food addiction whereas being overweight increases the likelihood of food addiction (<i>p</i> = 0.01*, 0.009*, 0.02*) respectively. Having sleep difficulties, anxiety, and smoking are positive significant predictors for food addiction (<i>p</i> = 0.03*, 0.001*, 0.001* respectively) which increases the possibility of acquiring food addiction.</p> Conclusion <p>In sum, this finding highlighted a higher prevalence of food addiction among medical university students. Moreover, university students with anxiety, sleep disturbances, overweight, or obesity; smokers; and males are more prone to food addiction. Further studies are crucial to assess and execute measures regarding food addiction among undergraduates.</p>