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<p>High-fat diets adversely affect both glycemic control and the composition of the intestinal microbiota. Yacon syrup, which is rich in fructooligosaccharides (FOS) and antioxidants, offers a promising nutritional solution. This study aimed to investigate the impact of Yacon syrup consumption on the intestinal microbiota profile, body weight, food consumption, and glycemic control in rats exposed to a high-fat diet (HFD). Our experimental design involved placing the animals into four distinct groups: (1) rats maintained on a standard diet throughout the experimental protocol, (2) rats consistently fed a high-fat diet, (3) rats exposed to an initial phase of HFD followed by HFD supplemented with 1% FOS in the second phase, and (4) rats following a similar two-phase HFD regimen but with 2% FOS supplementation. We carefully monitored dietary intake and conducted glucose tolerance tests. After the treatment, we performed a 16S rRNA gene analysis of the intestinal microbiota. Our findings revealed a notable increase in the glycemic peak within the first 15&#xa0;min of high-fat consumption when compared to the supplemented groups. Our findings, observed after 10&#xa0;weeks of treatment (phase 1, days 1–38; phase 2, days 39–70), revealed a notable increase in the glycemic peak within the first 15&#xa0;min in the group consistently fed a high-fat diet compared to the supplemented groups. Further, we observed a significant increase in specific pathogenic phyla (notably Proteobacteria and Firmicutes) in the group with rats consistently consuming a high-fat diet. There were no statistically significant differences in food intake between the experimental groups. The administration of Yacon syrup effectively mitigated the adverse effects of the high-fat diet on glycemic control and the composition of the intestinal microbiota. This underscores the prebiotic potential of Yacon syrup and its promise as a valuable dietary intervention in the context of high-fat diets.</p> Graphical abstract <p></p>

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Effects of Yacon (Smallanthus sonchifolius) syrup on the glycemic metabolism, and intestinal microbiota of rats on a high-fat diet

  • 期刊论文

  • 发表日期：

    2025年2月25日

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  • Bruna Kelly de Medeiros Andrade,
  • Milton Alves Danziato-Neto,
  • Ariclécio Cunha de Oliveira,
  • Paula Alexandre de Freitas,
  • Vânia Maria Maciel Melo,
  • Bárbara Cibelle Soares Farias Quintela,
  • Francisca Andréa da Silva Oliveira,
  • Ana Cristina de Oliveira Monteiro-Moreira,
  • Ana Paula Dionísio,
  • Lia Silveira Adriano,
  • Matheus Augusto Ferreira da Costa,
  • Izaak Ferreira Almeida,
  • Antonio Augusto Ferreira Carioca

摘要

High-fat diets adversely affect both glycemic control and the composition of the intestinal microbiota. Yacon syrup, which is rich in fructooligosaccharides (FOS) and antioxidants, offers a promising nutritional solution. This study aimed to investigate the impact of Yacon syrup consumption on the intestinal microbiota profile, body weight, food consumption, and glycemic control in rats exposed to a high-fat diet (HFD). Our experimental design involved placing the animals into four distinct groups: (1) rats maintained on a standard diet throughout the experimental protocol, (2) rats consistently fed a high-fat diet, (3) rats exposed to an initial phase of HFD followed by HFD supplemented with 1% FOS in the second phase, and (4) rats following a similar two-phase HFD regimen but with 2% FOS supplementation. We carefully monitored dietary intake and conducted glucose tolerance tests. After the treatment, we performed a 16S rRNA gene analysis of the intestinal microbiota. Our findings revealed a notable increase in the glycemic peak within the first 15 min of high-fat consumption when compared to the supplemented groups. Our findings, observed after 10 weeks of treatment (phase 1, days 1–38; phase 2, days 39–70), revealed a notable increase in the glycemic peak within the first 15 min in the group consistently fed a high-fat diet compared to the supplemented groups. Further, we observed a significant increase in specific pathogenic phyla (notably Proteobacteria and Firmicutes) in the group with rats consistently consuming a high-fat diet. There were no statistically significant differences in food intake between the experimental groups. The administration of Yacon syrup effectively mitigated the adverse effects of the high-fat diet on glycemic control and the composition of the intestinal microbiota. This underscores the prebiotic potential of Yacon syrup and its promise as a valuable dietary intervention in the context of high-fat diets.

Graphical abstract