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Context <p>Ginger (<i>Zingiber officinale</i> Roscoe) has been traditionally utilized in herbal medicine for its potential anti-obesity effects worldwide.</p> Aim <p>This study evaluated the therapeutic efficacy of diets supplemented with raw ginger (RG) and boiled ginger (BG) at 2% and 4% concentrations on hyperlipidemia in high cholesterol diet (HCD)-induced obesity in rats.</p> Methods <p>Seven groups of ten rats each were used: a healthy control group on a basal diet, an obese untreated group on HCD, a group treated with the reference drug orlistat (10&#xa0;mg/kg BW/day), and four groups fed HCD supplemented with either 2% or 4% RG or BG for 24&#xa0;weeks. Blood and liver samples were collected post-euthanasia for biochemical analyses.</p> Results <p>Both RG and BG supplementation significantly enhanced total antioxidant capacity and enzyme activities, including reduced glutathione, glutathione peroxidase, and catalase (<i>P</i> &lt; 0.05), while reducing liver marker enzyme activities, TBARS, total cholesterol, triglycerides, and LDL cholesterol. mRNA expressions of fatty acid synthase and other lipid-regulatory genes were down-regulated, whereas carnitine palmitoyltransferase-1 and apolipoprotein A1 were up-regulated in ginger-treated groups. Histological analysis indicated improved liver architecture in treated groups, with 4% BG demonstrating the most pronounced effects.</p> Conclusion <p>Boiled ginger, particularly at a 4% inclusion rate, is more effective than raw ginger in mitigating hyperlipidemia associated with a high-cholesterol diet, highlighting its potential as a dietary intervention for managing obesity-related metabolic disorders.</p>

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Effect of dietary supplementation with raw and boiled ginger (Zingiber officinale Roscoe) rhizome on biochemical parameters of rats fed high cholesterol diet

  • 期刊论文

  • 发表日期：

    2025年2月4日

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  • Seun F. Akomolafe,
  • David A. Atoyebi,
  • Mary Aderonke Bola Ogundare,
  • Ibikunle Akinlua

摘要

Context

Ginger (Zingiber officinale Roscoe) has been traditionally utilized in herbal medicine for its potential anti-obesity effects worldwide.

Aim

This study evaluated the therapeutic efficacy of diets supplemented with raw ginger (RG) and boiled ginger (BG) at 2% and 4% concentrations on hyperlipidemia in high cholesterol diet (HCD)-induced obesity in rats.

Methods

Seven groups of ten rats each were used: a healthy control group on a basal diet, an obese untreated group on HCD, a group treated with the reference drug orlistat (10 mg/kg BW/day), and four groups fed HCD supplemented with either 2% or 4% RG or BG for 24 weeks. Blood and liver samples were collected post-euthanasia for biochemical analyses.

Results

Both RG and BG supplementation significantly enhanced total antioxidant capacity and enzyme activities, including reduced glutathione, glutathione peroxidase, and catalase (P < 0.05), while reducing liver marker enzyme activities, TBARS, total cholesterol, triglycerides, and LDL cholesterol. mRNA expressions of fatty acid synthase and other lipid-regulatory genes were down-regulated, whereas carnitine palmitoyltransferase-1 and apolipoprotein A1 were up-regulated in ginger-treated groups. Histological analysis indicated improved liver architecture in treated groups, with 4% BG demonstrating the most pronounced effects.

Conclusion

Boiled ginger, particularly at a 4% inclusion rate, is more effective than raw ginger in mitigating hyperlipidemia associated with a high-cholesterol diet, highlighting its potential as a dietary intervention for managing obesity-related metabolic disorders.