Hepato-renal oxidative disturbances following acute β-adrenergic stimulation by isoprenaline in male Wistar rat: Attenuative role of taurine, a β-amino acid

Liver and renal damage manifests in patients with both acute and chronic heart failure. Meanwhile, dietary agents can influence pathogenesis of disease in several studies. Whether, taurine, a β-amino acid can ameliorate, oxidative disturbances caused by acute adrenergic stimulation remain incompletely understood. Hence, the study investigated the ameliorative impact of taurine on isoprenaline-induced hepatorenal toxicity.

Animals were exposed to isoprenaline (200 mg/kg ip) for two consecutive days thereafter treated with taurine (100 mg/kg ip) for 19 days. Following 21 days experimentation, animals were euthanized, blood and liver and kidney were collected for biochemical assays as well as histological studies.

Our result showed that taurine significantly reduces serum LDH, AST, ALT, ALP, creatinine and urea as well as hepatorenal malondialdehyde and nitrite against the insult caused by isoprenaline. Levels of GSH, GST, SOD and catalase were also improved with taurine therapy. Histoarchitectural alterations as well as hepatorenal fibrosis were markedly ameliorated following taurine therapy.

taurine ameliorated hepatorenal oxidative disturbances which lead to hepatocellular membrane disruption and renal dysfunction caused by isoprenaline.