Scholarlink

<p>Lung cancer remains one of the leading causes of cancer-related death worldwide, with a significant number of patients succumbing to the disease each year. Olea europaea, commonly known as the olive tree, offers a range of health benefits due to its rich content of antioxidants. In the present study, we have reported the green synthesis of a bimetallic nanocomposite of zinc and copper using the leaf extract of <i>Olea europae</i>a (Zn/Cu NCs@ <i>Olea europaea</i>). The nanoparticles were characterized using common chemical techniques. The antioxidant activity of Zn/Cu NCs@ <i>Olea europaea</i> was evaluated using the DPPH assay. The cytotoxicity and anti-lung cancer activity of Zn/Cu NCs@ <i>Olea europaea</i> were investigated using the MTT assay. The results of XRD analysis and FE-SEM imaging showed a crystalline structure for Zn/Cu NCs@ <i>Olea europaea</i> with a semi-spherical morphology and an average size of 49.37&#xa0;nm. Zn/Cu NCs@ <i>Olea europaea</i> scavenged the free radical DPPH with an IC<sub>50</sub> of 363.42 ± 5.02&#xa0;µg/mL. Furthermore, Zn/Cu NCs@ <i>Olea europaea</i> exhibited acceptable anti-lung cancer activity by preventing growth in the cell lines SK-MES-1, A-549, and LK-2 with IC<sub>50</sub> of 154.00 ± 1.83, 228.83 ± 10.59, and 250.55 ± 8.04&#xa0;µg/mL respectively. The NPs were inactive against the normal cell lines of HUVEC even at high concentrations. The results of the study indicate that Zn/Cu NCs@ <i>Olea europaea</i>, which is green synthesized with a sufficient nano size, can be considered a potent anti-lung cancer agent.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月17日

查看全文
  • Jing Sun,
  • Shu Mei Tang,
  • Jing Sun,
  • Wei Gao

摘要

Lung cancer remains one of the leading causes of cancer-related death worldwide, with a significant number of patients succumbing to the disease each year. Olea europaea, commonly known as the olive tree, offers a range of health benefits due to its rich content of antioxidants. In the present study, we have reported the green synthesis of a bimetallic nanocomposite of zinc and copper using the leaf extract of Olea europaea (Zn/Cu NCs@ Olea europaea). The nanoparticles were characterized using common chemical techniques. The antioxidant activity of Zn/Cu NCs@ Olea europaea was evaluated using the DPPH assay. The cytotoxicity and anti-lung cancer activity of Zn/Cu NCs@ Olea europaea were investigated using the MTT assay. The results of XRD analysis and FE-SEM imaging showed a crystalline structure for Zn/Cu NCs@ Olea europaea with a semi-spherical morphology and an average size of 49.37 nm. Zn/Cu NCs@ Olea europaea scavenged the free radical DPPH with an IC50 of 363.42 ± 5.02 µg/mL. Furthermore, Zn/Cu NCs@ Olea europaea exhibited acceptable anti-lung cancer activity by preventing growth in the cell lines SK-MES-1, A-549, and LK-2 with IC50 of 154.00 ± 1.83, 228.83 ± 10.59, and 250.55 ± 8.04 µg/mL respectively. The NPs were inactive against the normal cell lines of HUVEC even at high concentrations. The results of the study indicate that Zn/Cu NCs@ Olea europaea, which is green synthesized with a sufficient nano size, can be considered a potent anti-lung cancer agent.