Scholarlink

Background <p>Instrumental activities of daily living (IADL) disability and circadian syndrome (CirS) are risk factors for the incidence of cardiometabolic disease. Our study aimed to investigate the association between CirS, IADL disability and cardiometabolic multimorbidity (CMM) among middle-aged and older adults in China.</p> Methods <p>This study included 8085 participants in cross-sectional analysis and 5887 in longitudinal analysis. Logistic regression models were utilized to present associations between CirS and CMM. Cox proportion hazard regression models were performed to assess relationship between CirS and incident CMM. Furthermore, subgroups analyses were conducted to better stratify analyses and show the interaction of variables among specific population. Combined effects of CirS and IADL disability on CMM were conducted. Also, we showed mediating role of IADL disability in the association between CirS and progression to CMM.</p> Results <p>In cross-sectional analysis, CirS was associated with CMM after adjusting all potential covariates. Besides, the increasing number of components connected with CMM significantly and components ≥6 presented the most robust association. In longitudinal analysis 452 CMM events occurred during 7 years follow-up. CirS and increasing number of components still displayed strong link with CMM with hazard ratios (HRs) of 3.55 (95%CI: 2.92–4.31) in crude model and 1.87 (95%CI: 1.5–2.34) in Model3. Furthermore, the combined effects of IADL disability and CirS showed stronger association with CMM with HRs of 2.76 (95%CI: 2.04-3.72). Additionally, IADL disability mediated 8.37% of the effect of CirS on new-onset CMM.</p> Conclusions <p>Our study highlighted that CirS and increasing number of components associated with CMM. The combination of CirS and IADL disability was significantly associated with new-onset CMM. In addition, IADL disability mediated the effect of CirS on the progression to CMM, accounting for 8.37% of the total effect. Our findings provided new insights into prevention of CMM. </p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The role of instrumental activity of daily living disability in the association between circadian syndrome and cardiometabolic multimorbidity in Chinese middle-aged and older adults

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月1日

查看全文
  • Yunteng Fang,
  • Daying Wu,
  • Zhenghua Shi,
  • Jiayi Shen,
  • Enqian Liu,
  • Xiaoyan Wu,
  • Wuming Hu,
  • Lingchun Lv

摘要

Background

Instrumental activities of daily living (IADL) disability and circadian syndrome (CirS) are risk factors for the incidence of cardiometabolic disease. Our study aimed to investigate the association between CirS, IADL disability and cardiometabolic multimorbidity (CMM) among middle-aged and older adults in China.

Methods

This study included 8085 participants in cross-sectional analysis and 5887 in longitudinal analysis. Logistic regression models were utilized to present associations between CirS and CMM. Cox proportion hazard regression models were performed to assess relationship between CirS and incident CMM. Furthermore, subgroups analyses were conducted to better stratify analyses and show the interaction of variables among specific population. Combined effects of CirS and IADL disability on CMM were conducted. Also, we showed mediating role of IADL disability in the association between CirS and progression to CMM.

Results

In cross-sectional analysis, CirS was associated with CMM after adjusting all potential covariates. Besides, the increasing number of components connected with CMM significantly and components ≥6 presented the most robust association. In longitudinal analysis 452 CMM events occurred during 7 years follow-up. CirS and increasing number of components still displayed strong link with CMM with hazard ratios (HRs) of 3.55 (95%CI: 2.92–4.31) in crude model and 1.87 (95%CI: 1.5–2.34) in Model3. Furthermore, the combined effects of IADL disability and CirS showed stronger association with CMM with HRs of 2.76 (95%CI: 2.04-3.72). Additionally, IADL disability mediated 8.37% of the effect of CirS on new-onset CMM.

Conclusions

Our study highlighted that CirS and increasing number of components associated with CMM. The combination of CirS and IADL disability was significantly associated with new-onset CMM. In addition, IADL disability mediated the effect of CirS on the progression to CMM, accounting for 8.37% of the total effect. Our findings provided new insights into prevention of CMM.