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Aim <p>In recent years, some studies have suggested that obesity and hyperlipidemia play a crucial role in chronic kidney disease (CKD); however, more research is needed. This study investigated the predictive role of lipid profiles and anthropometric indices in the incidence of CKD.</p> Methods and materials <p>The study subjects were participants in the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD), a prospective cohort study that began in 2010. Demographic information, anthropometric indices including body weight (BW), waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-hip ratio (WHR), waist-height ratio (WHtR), body adiposity index (BAI), body roundness index (BRI), weight-adjusted waist index (WWI), A body shape index (ABSI), abdominal volume index (AVI), WC/height ratio, and hip/height ratio, as well as laboratory investigations (including lipid profile) were recorded. Development of CKD was determined in the follow-up visits ten years after the first visit.</p> Results <p>Out of the 6,935 patients (41% male), 3859 (55%) were diagnosed with CKD. After adjusting confounders including age, sex, marriage, job, education, and smoking, the analysis revealed that weight (RR = 1.010 (1.006–1.014), <i>p</i> &lt; 0.001), HC (RR = 1.011 (1.005–1.017), <i>p</i> &lt; 0.001), height (RR = 1.026 (1.018–1.034), <i>p</i> &lt; 0.001), WWI (RR = 0.917 (0.869–0.967), <i>p</i> &lt; 0.01), Arm/height (RR = 1.361 (1.109–1.671, <i>p</i> &lt; 0.01), and demispan/ height (RR = 1.361 (1.109–1.671) <i>p</i> &lt; 0.01) were independent predictors of CKD.</p> Conclusion <p>Anthropometric and lipid indices have the potential to identify individuals at higher risk of developing CKD. However, further research is necessary in this field.</p>

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Novel anthropometric and lipid indices as predictors of chronic kidney disease: insights from a decade-long cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月3日

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  • Ali Rezaee,
  • Susan Darroudi,
  • Aida Yavari,
  • Vahid Mahdavizadeh,
  • Motahhareh Karimoddini,
  • Farzam Kamrani,
  • Reza Salehi Manzari,
  • Ali Shariatikia,
  • Habibollah Esmaily,
  • Majid Ghayour-Mobarhan,
  • Mohsen Moohebati

摘要

Aim

In recent years, some studies have suggested that obesity and hyperlipidemia play a crucial role in chronic kidney disease (CKD); however, more research is needed. This study investigated the predictive role of lipid profiles and anthropometric indices in the incidence of CKD.

Methods and materials

The study subjects were participants in the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD), a prospective cohort study that began in 2010. Demographic information, anthropometric indices including body weight (BW), waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-hip ratio (WHR), waist-height ratio (WHtR), body adiposity index (BAI), body roundness index (BRI), weight-adjusted waist index (WWI), A body shape index (ABSI), abdominal volume index (AVI), WC/height ratio, and hip/height ratio, as well as laboratory investigations (including lipid profile) were recorded. Development of CKD was determined in the follow-up visits ten years after the first visit.

Results

Out of the 6,935 patients (41% male), 3859 (55%) were diagnosed with CKD. After adjusting confounders including age, sex, marriage, job, education, and smoking, the analysis revealed that weight (RR = 1.010 (1.006–1.014), p < 0.001), HC (RR = 1.011 (1.005–1.017), p < 0.001), height (RR = 1.026 (1.018–1.034), p < 0.001), WWI (RR = 0.917 (0.869–0.967), p < 0.01), Arm/height (RR = 1.361 (1.109–1.671, p < 0.01), and demispan/ height (RR = 1.361 (1.109–1.671) p < 0.01) were independent predictors of CKD.

Conclusion

Anthropometric and lipid indices have the potential to identify individuals at higher risk of developing CKD. However, further research is necessary in this field.